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1ayo

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{{Seed}}
 
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[[Image:1ayo.png|left|200px]]
 
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==RECEPTOR BINDING DOMAIN OF BOVINE ALPHA-2-MACROGLOBULIN==
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The line below this paragraph, containing "STRUCTURE_1ayo", creates the "Structure Box" on the page.
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<StructureSection load='1ayo' size='340' side='right'caption='[[1ayo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ayo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AYO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1ayo| PDB=1ayo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ayo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ayo OCA], [https://pdbe.org/1ayo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ayo RCSB], [https://www.ebi.ac.uk/pdbsum/1ayo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ayo ProSAT]</span></td></tr>
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</table>
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===RECEPTOR BINDING DOMAIN OF BOVINE ALPHA-2-MACROGLOBULIN===
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== Function ==
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[https://www.uniprot.org/uniprot/A2MG_BOVIN A2MG_BOVIN] Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9634697 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/1ayo_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9634697}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1AYO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AYO OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ayo ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of the receptor-binding domain of alpha 2-macroglobulin., Jenner L, Husted L, Thirup S, Sottrup-Jensen L, Nyborg J, Structure. 1998 May 15;6(5):595-604. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9634697 9634697]
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Husted, L.]]
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[[Category: Husted L]]
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[[Category: Jenner, L B.]]
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[[Category: Jenner LB]]
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[[Category: Nyborg, J.]]
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[[Category: Nyborg J]]
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[[Category: Sottrup-Jensen, L.]]
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[[Category: Sottrup-Jensen L]]
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[[Category: Thirup, S.]]
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[[Category: Thirup S]]
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[[Category: Macroglobulin]]
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[[Category: Receptor binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:52:28 2008''
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Current revision

RECEPTOR BINDING DOMAIN OF BOVINE ALPHA-2-MACROGLOBULIN

PDB ID 1ayo

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