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1b3p

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{{Seed}}
 
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[[Image:1b3p.png|left|200px]]
 
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==5'-D(*GP*GP*AP*GP*GP*AP*T)-3'==
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The line below this paragraph, containing "STRUCTURE_1b3p", creates the "Structure Box" on the page.
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<StructureSection load='1b3p' size='340' side='right'caption='[[1b3p]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1b3p]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B3P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b3p OCA], [https://pdbe.org/1b3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b3p RCSB], [https://www.ebi.ac.uk/pdbsum/1b3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b3p ProSAT]</span></td></tr>
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{{STRUCTURE_1b3p| PDB=1b3p | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BACKGROUND: Triplet repeat sequences are of considerable biological importance as the expansion of such tandem arrays can lead to the onset of a range of human diseases. Such sequences can self-pair via mismatch alignments to form higher order structures that have the potential to cause replication blocks, followed by strand slippage and sequence expansion. The all-purine d(GGA)n triplet repeat sequence is of particular interest because purines can align via G.G, A.A and G.A mismatch formation. RESULTS: We have solved the structure of the uniformly 13C,15N-labeled d(G1-G2-A3-G4-G5-A6-T7) sequence in 10 mM Na+ solution. This sequence adopts a novel twofold-symmetric duplex fold where interlocked V-shaped arrowhead motifs are aligned solely via interstrand G1.G4, G2.G5 and A3.A6 mismatch formation. The tip of the arrowhead motif is centered about the p-A3-p step, and symmetry-related local parallel-stranded duplex domains are formed by the G1-G2-A3 and G4-G5-A6 segments of partner strands. CONCLUSIONS: The purine-rich (GGA)n triplet repeat sequence is dispersed throughout the eukaryotic genome. Several features of the arrowhead duplex motif for the (GGA)2 triplet repeat provide a unique scaffold for molecular recognition. These include the large localized bend in the sugar-phosphate backbones, the segmental parallel-stranded alignment of strands and the exposure of the Watson-Crick edges of several mismatched bases.
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===5'-D(*GP*GP*AP*GP*GP*AP*T)-3'===
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Interlocked mismatch-aligned arrowhead DNA motifs.,Kettani A, Bouaziz S, Skripkin E, Majumdar A, Wang W, Jones RA, Patel DJ Structure. 1999 Jul 15;7(7):803-15. PMID:10425682<ref>PMID:10425682</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10425682}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1b3p" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10425682 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10425682}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3P OCA].
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[[Category: Bouaziz S]]
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[[Category: Jones RA]]
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==Reference==
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[[Category: Kettani A]]
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Interlocked mismatch-aligned arrowhead DNA motifs., Kettani A, Bouaziz S, Skripkin E, Majumdar A, Wang W, Jones RA, Patel DJ, Structure. 1999 Jul 15;7(7):803-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10425682 10425682]
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[[Category: Majumdar A]]
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[[Category: Bouaziz, S.]]
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[[Category: Patel DJ]]
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[[Category: Jones, R A.]]
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[[Category: Skripkin E]]
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[[Category: Kettani, A.]]
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[[Category: Wang W]]
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[[Category: Majumdar, A.]]
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[[Category: Patel, D J.]]
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[[Category: Skripkin, E.]]
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[[Category: Wang, W.]]
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[[Category: 15n-labeled dna]]
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[[Category: Mismatch alignment]]
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[[Category: Parallel-stranded segment]]
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[[Category: Uniform 13c]]
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[[Category: V-shaped backbone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:10:25 2008''
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Current revision

5'-D(*GP*GP*AP*GP*GP*AP*T)-3'

PDB ID 1b3p

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