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1b4y

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{{Seed}}
 
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[[Image:1b4y.png|left|200px]]
 
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==STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.==
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The line below this paragraph, containing "STRUCTURE_1b4y", creates the "Structure Box" on the page.
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<StructureSection load='1b4y' size='340' side='right'caption='[[1b4y]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1b4y]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B4Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b4y OCA], [https://pdbe.org/1b4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b4y RCSB], [https://www.ebi.ac.uk/pdbsum/1b4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b4y ProSAT]</span></td></tr>
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{{STRUCTURE_1b4y| PDB=1b4y | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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H-DNA, thought to play a regulatory role in transcription, exists in two isomeric forms, H-y3 and H-y5. We present the first solution structure of a DNA fragment representing the H-y5 fold. The structure shows the H-y5 triple helix, and for the first time how in an H-DNA isomer the purine strand extension interacts with the triplex loop. It gives direct insight into the mechanism of H-DNA formation, and explains a host of biochemical and biophysical data on the relative stability of the H-DNA isomers. In addition, the observed interaction of the purine strand extension and the triplex loop provides new clues to the design of clamp-type triple helix-forming oligonucleotides.
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===STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.===
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Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix.,van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:10467098<ref>PMID:10467098</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1b4y" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10467098 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10467098}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA].
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[[Category: Doreleijers JF]]
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[[Category: Hilbers CW]]
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==Reference==
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[[Category: Van Boom JH]]
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Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix., van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS, Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10467098 10467098]
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[[Category: Van Der Marel GA]]
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[[Category: Boom, J H.Van.]]
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[[Category: Van Dongen MJP]]
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[[Category: Dongen, M J.P Van.]]
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[[Category: Wijmenga SS]]
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[[Category: Doreleijers, J F.]]
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[[Category: Hilbers, C W.]]
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[[Category: Marel, G A.Van Der.]]
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[[Category: Wijmenga, S S.]]
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[[Category: Dna]]
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[[Category: H-dna]]
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[[Category: Triple helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:16:30 2008''
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Current revision

STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.

PDB ID 1b4y

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