1bc4

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{{Seed}}
 
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[[Image:1bc4.png|left|200px]]
 
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==THE SOLUTION STRUCTURE OF A CYTOTOXIC RIBONUCLEASE FROM THE OOCYTES OF RANA CATESBEIANA (BULLFROG), NMR, 15 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1bc4", creates the "Structure Box" on the page.
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<StructureSection load='1bc4' size='340' side='right'caption='[[1bc4]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bc4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_catesbeianus Lithobates catesbeianus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BC4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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{{STRUCTURE_1bc4| PDB=1bc4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bc4 OCA], [https://pdbe.org/1bc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bc4 RCSB], [https://www.ebi.ac.uk/pdbsum/1bc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bc4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNASO_LITCT RNASO_LITCT] Preferentially cleaves single-stranded RNA at pyrimidine residues with a 3'flanking guanine. Hydrolyzes poly(U) and poly(C) as substrates, and prefers the former. The S-lectins in frog eggs may be involved in the fertilization and development of the frog embryo. This lectin agglutinates various animal cells, including normal lymphocytes, erythrocytes, and fibroblasts of animal and human origin. It is cytotoxic against several tumor cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/1bc4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bc4 ConSurf].
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<div style="clear:both"></div>
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===THE SOLUTION STRUCTURE OF A CYTOTOXIC RIBONUCLEASE FROM THE OOCYTES OF RANA CATESBEIANA (BULLFROG), NMR, 15 STRUCTURES===
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==See Also==
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9761686}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9761686 is the PubMed ID number.
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[[Category: Lithobates catesbeianus]]
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[[Category: Chang C-F]]
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{{ABSTRACT_PUBMED_9761686}}
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[[Category: Chen C]]
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[[Category: Chen Y-C]]
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==About this Structure==
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[[Category: Hom K]]
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1BC4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BC4 OCA].
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[[Category: Huang R-F]]
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[[Category: Huang T]]
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==Reference==
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The solution structure of a cytotoxic ribonuclease from the oocytes of Rana catesbeiana (bullfrog)., Chang CF, Chen C, Chen YC, Hom K, Huang RF, Huang TH, J Mol Biol. 1998;283(1):231-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9761686 9761686]
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[[Category: Pancreatic ribonuclease]]
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[[Category: Rana catesbeiana]]
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[[Category: Single protein]]
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[[Category: Chang, C F.]]
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[[Category: Chen, C.]]
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[[Category: Chen, Y C.]]
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[[Category: Hom, K.]]
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[[Category: Huang, R F.]]
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[[Category: Huang, T.]]
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[[Category: Cytotoxic protein]]
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[[Category: Hydrolase]]
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[[Category: Phosphoric diester]]
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[[Category: Rc-rnase]]
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[[Category: Sialic acid binding lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:48:16 2008''
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Current revision

THE SOLUTION STRUCTURE OF A CYTOTOXIC RIBONUCLEASE FROM THE OOCYTES OF RANA CATESBEIANA (BULLFROG), NMR, 15 STRUCTURES

PDB ID 1bc4

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