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1bcg
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1bcg.png|left|200px]] | ||
| - | + | ==SCORPION TOXIN BJXTR-IT== | |
| - | + | <StructureSection load='1bcg' size='340' side='right'caption='[[1bcg]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1bcg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hottentotta_judaicus Hottentotta judaicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BCG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bcg OCA], [https://pdbe.org/1bcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bcg RCSB], [https://www.ebi.ac.uk/pdbsum/1bcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bcg ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/SIXE_HOTJU SIXE_HOTJU] Excitatory insect toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects. | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | < | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/1bcg_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | == | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bcg ConSurf]. |
| - | + | <div style="clear:both"></div> | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | + | ||
[[Category: Hottentotta judaicus]] | [[Category: Hottentotta judaicus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Amit | + | [[Category: Amit E]] |
| - | [[Category: Froy | + | [[Category: Froy O]] |
| - | [[Category: Gurevitz | + | [[Category: Gurevitz M]] |
| - | [[Category: Kleinberger-Doron | + | [[Category: Kleinberger-Doron N]] |
| - | [[Category: Oren | + | [[Category: Oren D]] |
| - | [[Category: Shaanan | + | [[Category: Shaanan B]] |
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Current revision
SCORPION TOXIN BJXTR-IT
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