This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1bet

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:32, 13 March 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1bet.png|left|200px]]
 
-
<!--
+
==NEW PROTEIN FOLD REVEALED BY A 2.3 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF NERVE GROWTH FACTOR==
-
The line below this paragraph, containing "STRUCTURE_1bet", creates the "Structure Box" on the page.
+
<StructureSection load='1bet' size='340' side='right'caption='[[1bet]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1bet]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The August 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Neurotrophins'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_8 10.2210/rcsb_pdb/mom_2005_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BET FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bet OCA], [https://pdbe.org/1bet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bet RCSB], [https://www.ebi.ac.uk/pdbsum/1bet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bet ProSAT]</span></td></tr>
-
{{STRUCTURE_1bet| PDB=1bet | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NGF_MOUSE NGF_MOUSE] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/1bet_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bet ConSurf].
 +
<div style="clear:both"></div>
-
===NEW PROTEIN FOLD REVEALED BY A 2.3 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF NERVE GROWTH FACTOR===
+
==See Also==
-
 
+
*[[Nerve growth factor|Nerve growth factor]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_1956407}}, adds the Publication Abstract to the page
+
[[Category: Large Structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 1956407 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_1956407}}
+
-
 
+
-
==About this Structure==
+
-
1BET is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The following page contains interesting information on the relation of 1BET with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb68_1.html Neurotrophins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BET OCA].
+
-
 
+
-
==Reference==
+
-
New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor., McDonald NQ, Lapatto R, Murray-Rust J, Gunning J, Wlodawer A, Blundell TL, Nature. 1991 Dec 5;354(6352):411-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1956407 1956407]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Neurotrophins]]
[[Category: Neurotrophins]]
-
[[Category: Single protein]]
+
[[Category: RCSB PDB Molecule of the Month]]
-
[[Category: Blundell, T L.]]
+
[[Category: Blundell TL]]
-
[[Category: Gunning, J.]]
+
[[Category: Gunning J]]
-
[[Category: Lapatto, R.]]
+
[[Category: Lapatto R]]
-
[[Category: Mcdonald, N Q.]]
+
[[Category: Mcdonald NQ]]
-
[[Category: Murray-Rust, J.]]
+
[[Category: Murray-Rust J]]
-
[[Category: Wlodawer, A.]]
+
[[Category: Wlodawer A]]
-
[[Category: Growth factor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:59:58 2008''
+

Current revision

NEW PROTEIN FOLD REVEALED BY A 2.3 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF NERVE GROWTH FACTOR

PDB ID 1bet

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bet"
Personal tools