1ecr

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(New page: 200px<br /><applet load="1ecr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ecr, resolution 2.700&Aring;" /> '''ESCHERICHIA COLI RE...)
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[[Image:1ecr.gif|left|200px]]<br /><applet load="1ecr" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ecr, resolution 2.700&Aring;" />
 
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'''ESCHERICHIA COLI REPLICATION TERMINATOR PROTEIN (TUS) COMPLEXED WITH DNA'''<br />
 
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==Overview==
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==ESCHERICHIA COLI REPLICATION TERMINATOR PROTEIN (TUS) COMPLEXED WITH DNA==
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The crystal structure of the Escherichia coli replication-terminator, protein (Tus) bound to terminus-site (Ter) DNA has been determined at 2.7, A resolution. The Tus protein folds into a previously undescribed, architecture divided into two domains by a central basic cleft. This cleft, accommodates locally deformed B-form Ter DNA and makes extensive contacts, with the major groove, mainly through two interdomain beta-strands. The, unusual structural features of this complex may explain how the, replication fork is halted in only one direction.
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<StructureSection load='1ecr' size='340' side='right'caption='[[1ecr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ecr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B Escherichia coli B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ECR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ECR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ecr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ecr OCA], [https://pdbe.org/1ecr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ecr RCSB], [https://www.ebi.ac.uk/pdbsum/1ecr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ecr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TUS_ECOLI TUS_ECOLI] Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/1ecr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ecr ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1ECR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ECR OCA].
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*[[Replication Termination Protein|Replication Termination Protein]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of a replication-terminator protein complexed with DNA., Kamada K, Horiuchi T, Ohsumi K, Shimamoto N, Morikawa K, Nature. 1996 Oct 17;383(6601):598-603. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8857533 8857533]
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[[Category: Escherichia coli B]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Kamada K]]
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[[Category: Kamada, K.]]
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[[Category: Morikawa K]]
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[[Category: Morikawa, K.]]
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[[Category: complex (dna-binding protein/dna)]]
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[[Category: dna replication]]
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[[Category: dna-binding]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:54:10 2007''
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Current revision

ESCHERICHIA COLI REPLICATION TERMINATOR PROTEIN (TUS) COMPLEXED WITH DNA

PDB ID 1ecr

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