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1bgz

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{{Seed}}
 
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[[Image:1bgz.png|left|200px]]
 
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==S8 RRNA BINDING SITE FROM E. COLI, NMR, 6 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1bgz", creates the "Structure Box" on the page.
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<StructureSection load='1bgz' size='340' side='right'caption='[[1bgz]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bgz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BGZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bgz OCA], [https://pdbe.org/1bgz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bgz RCSB], [https://www.ebi.ac.uk/pdbsum/1bgz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bgz ProSAT]</span></td></tr>
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{{STRUCTURE_1bgz| PDB=1bgz | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many cellular processes involve the preferential interaction of an RNA molecule with a specific protein. A detailed analysis of the individual protein and RNA components of these interactions can provide unique insights into the structural features important for protein-RNA recognition. Ribosomal protein S8 of Escherichia coli plays a key role in 30 S ribosomal subunit assembly through its interaction with 16 S rRNA. The binding site for protein S8 comprises a portion of helix 21, nucleotides G588 to G604 and C634 to C651. This region forms a base-paired helix that is interrupted by a non-Watson-Crick segment composed of nine phylogenetically conserved nucleotides. We have investigated the detailed structure of the conserved segment and the interaction of this region with metal ions using NMR spectroscopy. Twenty-four of the 40 calculated structures converged to similar conformations and were grouped into two families. The main difference between the families is the orientation of the base of U641. The rms deviation between the heavy-atoms of the ten lowest-energy structures is 1.24 A. The orientations of the G597.C643 base-pair and A595.(A596.U644) base-triple within the conserved core have been defined and appear to extend the proximal segment of helix 21 into the phylogenetically conserved core. The base of A642 terminates this helix by stacking against C643 and the base of U641 forms hydrogen bonds with core nucleotides. The conserved core also contains a Mg2+-binding site that promotes stabilization of the secondary and tertiary structure elements of the core. A model for the interaction of S8 with its RNA-binding site is proposed.
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===S8 RRNA BINDING SITE FROM E. COLI, NMR, 6 STRUCTURES===
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NMR structure determination of the binding site for ribosomal protein S8 from Escherichia coli 16 S rRNA.,Kalurachchi K, Nikonowicz EP J Mol Biol. 1998 Jul 24;280(4):639-54. PMID:9677294<ref>PMID:9677294</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_9677294}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1bgz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9677294 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9677294}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BGZ OCA].
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[[Category: Kalurachchi K]]
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[[Category: Nikonowicz EP]]
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==Reference==
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NMR structure determination of the binding site for ribosomal protein S8 from Escherichia coli 16 S rRNA., Kalurachchi K, Nikonowicz EP, J Mol Biol. 1998 Jul 24;280(4):639-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9677294 9677294]
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[[Category: Kalurachchi, K.]]
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[[Category: Nikonowicz, E P.]]
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[[Category: 16s rrna]]
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[[Category: Base triple]]
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[[Category: Internal loop]]
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[[Category: Ribonucleic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:08:50 2008''
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Current revision

S8 RRNA BINDING SITE FROM E. COLI, NMR, 6 STRUCTURES

PDB ID 1bgz

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