1bt2

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{{Seed}}
 
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[[Image:1bt2.png|left|200px]]
 
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==CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES) IN THE REDUCED CU(I)-CU(I) STATE==
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The line below this paragraph, containing "STRUCTURE_1bt2", creates the "Structure Box" on the page.
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<StructureSection load='1bt2' size='340' side='right'caption='[[1bt2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bt2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BT2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2O:CU-O-CU+LINKAGE'>C2O</scene></td></tr>
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{{STRUCTURE_1bt2| PDB=1bt2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bt2 OCA], [https://pdbe.org/1bt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bt2 RCSB], [https://www.ebi.ac.uk/pdbsum/1bt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bt2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPO1_IPOBA PPO1_IPOBA] Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/1bt2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bt2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Catechol oxidases are ubiquitous plant enzymes containing a dinuclear copper center. In the wound-response mechanism of the plant they catalyze the oxidation of a broad range of ortho-diphenols to the corresponding o-quinones coupled with the reduction of oxygen to water. The crystal structures of the enzyme from sweet potato in the resting dicupric Cu(II)-Cu(II) state, the reduced dicuprous Cu(I)-Cu(I) form, and in complex with the inhibitor phenylthiourea were analyzed. The catalytic copper center is accommodated in a central four-helix-bundle located in a hydrophobic pocket close to the surface. Both metal binding sites are composed of three histidine ligands. His 109, ligated to the CuA site, is covalently linked to Cys 92 by an unusual thioether bond. Based on biochemical, spectroscopic and the presented structural data, a catalytical mechanism is proposed in which one of the oxygen atoms of the diphenolic substrate binds to CuB of the oxygenated enzyme.
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===CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES) IN THE REDUCED CU(I)-CU(I) STATE===
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Crystal structure of a plant catechol oxidase containing a dicopper center.,Klabunde T, Eicken C, Sacchettini JC, Krebs B Nat Struct Biol. 1998 Dec;5(12):1084-90. PMID:9846879<ref>PMID:9846879</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9846879}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1bt2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9846879 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9846879}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1BT2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BT2 OCA].
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==Reference==
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Crystal structure of a plant catechol oxidase containing a dicopper center., Klabunde T, Eicken C, Sacchettini JC, Krebs B, Nat Struct Biol. 1998 Dec;5(12):1084-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9846879 9846879]
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[[Category: Catechol oxidase]]
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[[Category: Ipomoea batatas]]
[[Category: Ipomoea batatas]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Eicken, C.]]
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[[Category: Eicken C]]
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[[Category: Klabunde, T.]]
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[[Category: Klabunde T]]
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[[Category: Krebs, B.]]
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[[Category: Krebs B]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sacchettini JC]]
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[[Category: Catechol oxidase]]
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[[Category: Dicopper enzyme]]
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[[Category: Ipomoea batata]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:40:50 2008''
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Current revision

CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES) IN THE REDUCED CU(I)-CU(I) STATE

PDB ID 1bt2

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