1bv8

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{{Seed}}
 
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[[Image:1bv8.png|left|200px]]
 
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==RECEPTOR DOMAIN FROM ALPHA-2-MACROGLOBULIN==
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The line below this paragraph, containing "STRUCTURE_1bv8", creates the "Structure Box" on the page.
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<StructureSection load='1bv8' size='340' side='right'caption='[[1bv8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BV8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bv8 OCA], [https://pdbe.org/1bv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bv8 RCSB], [https://www.ebi.ac.uk/pdbsum/1bv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bv8 ProSAT]</span></td></tr>
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{{STRUCTURE_1bv8| PDB=1bv8 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A2MG_HUMAN A2MG_HUMAN] Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/1bv8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bv8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The low density lipoprotein receptor-related protein is a member of the low density lipoprotein receptor family and contains clusters of cysteine-rich complement-like repeats of about 42 residues that are present in all members of this family of receptors. These clusters are thought to be the principal binding sites for protein ligands. We have expressed one complement-like repeat, CR8, from the cluster in lipoprotein receptor-related protein that binds certain proteinase inhibitor-proteinase complexes and used three-dimensional NMR on the 13C/15N-labeled protein to determine the structure in solution of the calcium-bound form. The structure is very similar in overall fold to repeat 5 from the low density lipoprotein receptor (LB5), with backbone root mean square deviation of 1.5 A. The calcium-binding site also appears to be homologous, with four carboxyl and two backbone carbonyl ligands. However, differences in primary structure are such that equivalent surfaces that might represent the binding interfaces are very different from one another, indicating that different domains will have very different ligand specificities.
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===RECEPTOR DOMAIN FROM ALPHA-2-MACROGLOBULIN===
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NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein.,Huang W, Dolmer K, Gettins PG J Biol Chem. 1999 May 14;274(20):14130-6. PMID:10318830<ref>PMID:10318830</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10318830}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1bv8" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10318830 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10318830}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1BV8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV8 OCA].
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==Reference==
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NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein., Huang W, Dolmer K, Gettins PG, J Biol Chem. 1999 May 14;274(20):14130-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10318830 10318830]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dolmer, K.]]
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[[Category: Dolmer K]]
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[[Category: Gettins, P G.W.]]
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[[Category: Gettins PGW]]
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[[Category: Huang, W.]]
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[[Category: Huang W]]
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[[Category: Liao, X.]]
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[[Category: Liao X]]
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[[Category: Proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:46:13 2008''
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Current revision

RECEPTOR DOMAIN FROM ALPHA-2-MACROGLOBULIN

PDB ID 1bv8

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