1bxl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:20, 22 May 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1bxl.png|left|200px]]
 
-
<!--
+
==STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE==
-
The line below this paragraph, containing "STRUCTURE_1bxl", creates the "Structure Box" on the page.
+
<StructureSection load='1bxl' size='340' side='right'caption='[[1bxl]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1bxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BXL FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxl OCA], [https://pdbe.org/1bxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bxl RCSB], [https://www.ebi.ac.uk/pdbsum/1bxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bxl ProSAT]</span></td></tr>
-
{{STRUCTURE_1bxl| PDB=1bxl | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/1bxl_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bxl ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for heterodimer formation was investigated by determination of the solution structure of a complex between the survival protein Bcl-xL and the death-promoting region of the Bcl-2-related protein Bak. The structure and binding affinities of mutant Bak peptides indicate that the Bak peptide adopts an amphipathic alpha helix that interacts with Bcl-xL through hydrophobic and electrostatic interactions. Mutations in full-length Bak that disrupt either type of interaction inhibit the ability of Bak to heterodimerize with Bcl-xL.
-
===STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE===
+
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.,Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB, Fesik SW Science. 1997 Feb 14;275(5302):983-6. PMID:9020082<ref>PMID:9020082</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1bxl" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_9020082}}, adds the Publication Abstract to the page
+
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 9020082 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_9020082}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1BXL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXL OCA].
+
-
 
+
-
==Reference==
+
-
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis., Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB, Fesik SW, Science. 1997 Feb 14;275(5302):983-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9020082 9020082]
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Protein complex]]
+
[[Category: Homo sapiens]]
-
[[Category: Chang, B S.]]
+
[[Category: Large Structures]]
-
[[Category: Eberstadt, M.]]
+
[[Category: Chang BS]]
-
[[Category: Fesik, S W.]]
+
[[Category: Eberstadt M]]
-
[[Category: Harlan, J E.]]
+
[[Category: Fesik SW]]
-
[[Category: Liang, H.]]
+
[[Category: Harlan JE]]
-
[[Category: Meadows, R P.]]
+
[[Category: Liang H]]
-
[[Category: Minn, A J.]]
+
[[Category: Meadows RP]]
-
[[Category: Nettesheim, D.]]
+
[[Category: Minn AJ]]
-
[[Category: Sattler, M.]]
+
[[Category: Nettesheim D]]
-
[[Category: Shuker, S B.]]
+
[[Category: Sattler M]]
-
[[Category: Thompson, C B.]]
+
[[Category: Shuker SB]]
-
[[Category: Yoon, H.]]
+
[[Category: Thompson CB]]
-
[[Category: Alternative splicing]]
+
[[Category: Yoon H]]
-
[[Category: Apoptosis]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:52:42 2008''
+

Current revision

STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1bxl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bxl"
Personal tools