1byj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (23:22, 27 December 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1byj.png|left|200px]]
 
-
<!--
+
==GENTAMICIN C1A A-SITE COMPLEX==
-
The line below this paragraph, containing "STRUCTURE_1byj", creates the "Structure Box" on the page.
+
<StructureSection load='1byj' size='340' side='right'caption='[[1byj]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1byj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BYJ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GE1:3,4-DIDEOXY-2,6-AMINO-ALPHA-D+GALACTOPYRANOSE'>GE1</scene>, <scene name='pdbligand=GE2:3,5-DIAMINO-CYCLOHEXANOL'>GE2</scene>, <scene name='pdbligand=GE3:5-METHYL-4-METHYLAMINO-TETRAHYDRO-PYRAN-2,3,5-TRIOL'>GE3</scene></td></tr>
-
{{STRUCTURE_1byj| PDB=1byj | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1byj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byj OCA], [https://pdbe.org/1byj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1byj RCSB], [https://www.ebi.ac.uk/pdbsum/1byj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1byj ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Aminoglycoside antibiotics that bind to the ribosomal A site cause misreading of the genetic code and inhibit translocation. The clinically important aminoglycoside, gentamicin C, is a mixture of three components. Binding of each gentamicin component to the ribosome and to a model RNA oligonucleotide was studied biochemically and the structure of the RNA complexed to gentamicin C1a was solved using magnetic resonance nuclear spectroscopy. Gentamicin C1a binds in the major groove of the RNA. Rings I and II of gentamicin direct specific RNA-drug interactions. Ring III of gentamicin, which distinguishes this subclass of aminoglycosides, also directs specific RNA interactions with conserved base pairs. The structure leads to a general model for specific ribosome recognition by aminoglycoside antibiotics and a possible mechanism for translational inhibition and miscoding. This study provides a structural rationale for chemical synthesis of novel aminoglycosides.
-
===GENTAMICIN C1A A-SITE COMPLEX===
+
Structural origins of gentamicin antibiotic action.,Yoshizawa S, Fourmy D, Puglisi JD EMBO J. 1998 Nov 16;17(22):6437-48. PMID:9822590<ref>PMID:9822590</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_9822590}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1byj" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 9822590 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_9822590}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYJ OCA].
+
[[Category: Fourmy D]]
-
 
+
[[Category: Puglisi JD]]
-
==Reference==
+
[[Category: Yoshizawa S]]
-
Structural origins of gentamicin antibiotic action., Yoshizawa S, Fourmy D, Puglisi JD, EMBO J. 1998 Nov 16;17(22):6437-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9822590 9822590]
+
-
[[Category: Fourmy, D.]]
+
-
[[Category: Puglisi, J D.]]
+
-
[[Category: Yoshizawa, S.]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:57:13 2008''
+

Current revision

GENTAMICIN C1A A-SITE COMPLEX

PDB ID 1byj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1byj"
Personal tools