1byy

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{{Seed}}
 
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[[Image:1byy.png|left|200px]]
 
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==SODIUM CHANNEL IIA INACTIVATION GATE==
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The line below this paragraph, containing "STRUCTURE_1byy", creates the "Structure Box" on the page.
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<StructureSection load='1byy' size='340' side='right'caption='[[1byy]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1byy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BYY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1byy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byy OCA], [https://pdbe.org/1byy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1byy RCSB], [https://www.ebi.ac.uk/pdbsum/1byy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1byy ProSAT]</span></td></tr>
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{{STRUCTURE_1byy| PDB=1byy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCN2A_RAT SCN2A_RAT] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/1byy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1byy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The sodium channel initiates action potentials by opening in response to membrane depolarization. Fast channel inactivation, which is required for proper physiological function, is mediated by a cytoplasmic loop proposed to occlude the ion pore via a hinged lid mechanism with the triad IFM serving as a hydrophobic "latch". The NMR solution structure of the isolated inactivation gate reveals a stably folded core comprised of an alpha-helix capped by an N-terminal turn, supporting a model in which the tightly folded core containing the latch motif pivots on a more flexible hinge region to occlude the pore during inactivation. The structure, in combination with substituted cysteine mutagenesis experiments, indicates that the IFM triad and adjacent Thr are essential components of the latch and suggests differing roles for the residues of the IFMT motif in fast inactivation.
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===SODIUM CHANNEL IIA INACTIVATION GATE===
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Solution structure of the sodium channel inactivation gate.,Rohl CA, Boeckman FA, Baker C, Scheuer T, Catterall WA, Klevit RE Biochemistry. 1999 Jan 19;38(3):855-61. PMID:9893979<ref>PMID:9893979</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1byy" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9893979}}, adds the Publication Abstract to the page
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9893979 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9893979}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1BYY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYY OCA].
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==Reference==
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Solution structure of the sodium channel inactivation gate., Rohl CA, Boeckman FA, Baker C, Scheuer T, Catterall WA, Klevit RE, Biochemistry. 1999 Jan 19;38(3):855-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9893979 9893979]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Baker C]]
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[[Category: Baker, C.]]
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[[Category: Boeckman FA]]
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[[Category: Boeckman, F A.]]
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[[Category: Catterall WA]]
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[[Category: Catterall, W A.]]
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[[Category: Klevit RE]]
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[[Category: Klevit, R E.]]
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[[Category: Rohl CA]]
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[[Category: Rohl, C A.]]
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[[Category: Scheuer T]]
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[[Category: Scheuer, T.]]
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[[Category: Sodium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:58:20 2008''
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Current revision

SODIUM CHANNEL IIA INACTIVATION GATE

PDB ID 1byy

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