1c1f

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{{Seed}}
 
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[[Image:1c1f.png|left|200px]]
 
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==LIGAND-FREE CONGERIN I==
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The line below this paragraph, containing "STRUCTURE_1c1f", creates the "Structure Box" on the page.
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<StructureSection load='1c1f' size='340' side='right'caption='[[1c1f]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1c1f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1F FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_1c1f| PDB=1c1f | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1f OCA], [https://pdbe.org/1c1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1f RCSB], [https://www.ebi.ac.uk/pdbsum/1c1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEG1_CONMY LEG1_CONMY] This protein binds beta-galactoside. Its physiological function is not yet known.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c1f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BACKGROUND: Congerin I is a member of the galectin (animal beta-galactoside-binding lectin) family and is found in the skin mucus of conger eel. The galectin family proteins perform a variety of biological activities. Because of its histological localization and activity against marine bacteria and starfish embryos, congerin I is thought to take part in the eels' biological defense system against parasites. RESULTS: The crystal structure of congerin I has been determined in both lactose-liganded and ligand-free forms to 1. 5 A and 1.6 A resolution, respectively. The protein is a homodimer of 15 kDa subunits. Congerin I has a beta-sheet topology that is markedly different from those of known relatives. One of the beta-strands is exchanged between two identical subunits. This strand swap might increase the dimer stability. Of the known galectin complexes, congerin I forms the most extensive interaction with lactose molecules. Most of these interactions are substituted by similar interactions with water molecules, including a pi-electron hydrogen bond, in the ligand-free form. This observation indicates an increased affinity of congerin I for the ligand. CONCLUSIONS: The genes for congerin I and an isoform, congerin II, are known to have evolved under positive selection pressure. The strand swap and the modification in the carbohydrate-binding site might enhance the cross-linking activity, and should be the most apparent consequence of positive selection. The protein has been adapted to functioning in skin mucus that is in direct contact with surrounding environments by an enhancement in cross-linking activity. The structure of congerin I demonstrates the emergence of a new structure class by accelerated evolution under selection pressure.
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===LIGAND-FREE CONGERIN I===
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High-resolution structure of the conger eel galectin, congerin I, in lactose-liganded and ligand-free forms: emergence of a new structure class by accelerated evolution.,Shirai T, Mitsuyama C, Niwa Y, Matsui Y, Hotta H, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K Structure. 1999 Oct 15;7(10):1223-33. PMID:10545323<ref>PMID:10545323</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10545323}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1c1f" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10545323 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10545323}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1C1F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1F OCA].
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==Reference==
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High-resolution structure of the conger eel galectin, congerin I, in lactose-liganded and ligand-free forms: emergence of a new structure class by accelerated evolution., Shirai T, Mitsuyama C, Niwa Y, Matsui Y, Hotta H, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K, Structure. 1999 Oct 15;7(10):1223-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10545323 10545323]
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[[Category: Conger myriaster]]
[[Category: Conger myriaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hotta, H.]]
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[[Category: Hotta H]]
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[[Category: Ishii, C.]]
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[[Category: Ishii C]]
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[[Category: Kamiya, H.]]
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[[Category: Kamiya H]]
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[[Category: Matsui, Y.]]
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[[Category: Matsui Y]]
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[[Category: Mitsuyama, C.]]
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[[Category: Mitsuyama C]]
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[[Category: Muramoto, K.]]
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[[Category: Muramoto K]]
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[[Category: Niwa, Y.]]
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[[Category: Niwa Y]]
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[[Category: Ogawa, T.]]
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[[Category: Ogawa T]]
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[[Category: Shirai, T.]]
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[[Category: Shirai T]]
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[[Category: Yamane, T.]]
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[[Category: Yamane T]]
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[[Category: Beta-galactose-binding]]
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[[Category: Galectin]]
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[[Category: Lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:04:31 2008''
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Current revision

LIGAND-FREE CONGERIN I

PDB ID 1c1f

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