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1c48
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1c48.png|left|200px]] | ||
| - | + | ==MUTATED SHIGA-LIKE TOXIN B SUBUNIT (G62T)== | |
| - | + | <StructureSection load='1c48' size='340' side='right'caption='[[1c48]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1c48]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Phage_h30 Phage h30]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C48 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c48 OCA], [https://pdbe.org/1c48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c48 RCSB], [https://www.ebi.ac.uk/pdbsum/1c48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c48 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/STXB_BPH30 STXB_BPH30] The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/1c48_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c48 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Shiga toxin 3D structures|Shiga toxin 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
[[Category: Phage h30]] | [[Category: Phage h30]] | ||
| - | + | [[Category: Bast D]] | |
| - | [[Category: Bast | + | [[Category: Brunton JL]] |
| - | [[Category: Brunton | + | [[Category: Ling H]] |
| - | [[Category: Ling | + | [[Category: Read RJ]] |
| - | [[Category: Read | + | |
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Current revision
MUTATED SHIGA-LIKE TOXIN B SUBUNIT (G62T)
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Categories: Large Structures | Phage h30 | Bast D | Brunton JL | Ling H | Read RJ
