1eo6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1eo6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1eo6, resolution 1.8&Aring;" /> '''CRYSTAL STRUCTURE OF ...)
Current revision (07:05, 7 February 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1eo6.gif|left|200px]]<br /><applet load="1eo6" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1eo6, resolution 1.8&Aring;" />
 
-
'''CRYSTAL STRUCTURE OF GATE-16'''<br />
 
-
==Overview==
+
==CRYSTAL STRUCTURE OF GATE-16==
-
The GATE-16 protein participates in intra-Golgi transport and can, associate with the N-ethylmaleimide-sensitive fusion protein and with, Golgi SNAREs. The yeast ortholog of GATE-16 is the autophagocytosis factor, Aut7p. GATE-16 is also closely related to the GABA receptor-associated, protein (GABARAP), which has been proposed to cluster neurotransmitter, receptors by mediating interaction with the cytoskeleton, and to the light, chain-3 subunit of the neuronal microtubule-associated protein complex., Here, we present the crystal structure of GATE-16 refined to 1.8 A, resolution. GATE-16 contains a ubiquitin fold decorated by two additional, N-terminal helices. Proteins with strong structural similarity but no, detectable sequence homology to GATE-16 include Ras effectors that mediate, diverse downstream functions, but each interacts with Ras by forming, pseudo-continuous beta-sheets. The GATE-16 surface suggests that it binds, its targets in a similar manner. Moreover, a second potential, protein-protein interaction site on GATE-16 may explain the adapter, activity observed for members of the GATE-16 family.
+
<StructureSection load='1eo6' size='340' side='right'caption='[[1eo6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1eo6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EO6 FirstGlance]. <br>
-
1EO6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EO6 OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eo6 OCA], [https://pdbe.org/1eo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eo6 RCSB], [https://www.ebi.ac.uk/pdbsum/1eo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eo6 ProSAT]</span></td></tr>
-
==Reference==
+
</table>
-
Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p., Paz Y, Elazar Z, Fass D, J Biol Chem. 2000 Aug 18;275(33):25445-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10856287 10856287]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/GBRL2_BOVIN GBRL2_BOVIN] Involved in autophagy (By similarity). Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.<ref>PMID:10747018</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/1eo6_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eo6 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Elazar, Z.]]
+
[[Category: Elazar Z]]
-
[[Category: Fass, D.]]
+
[[Category: Fass D]]
-
[[Category: Paz, Y.]]
+
[[Category: Paz Y]]
-
[[Category: ubiquitin fold]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:10:16 2007''
+

Current revision

CRYSTAL STRUCTURE OF GATE-16

PDB ID 1eo6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1eo6"
Personal tools