1ce0

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[[Image:1ce0.png|left|200px]]
 
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==TRIMERIZATION SPECIFICITY IN HIV-1 GP41: ANALYSIS WITH A GCN4 LEUCINE ZIPPER MODEL==
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The line below this paragraph, containing "STRUCTURE_1ce0", creates the "Structure Box" on the page.
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<StructureSection load='1ce0' size='340' side='right'caption='[[1ce0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ce0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CE0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ce0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ce0 OCA], [https://pdbe.org/1ce0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ce0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ce0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ce0 ProSAT]</span></td></tr>
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{{STRUCTURE_1ce0| PDB=1ce0 | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/1ce0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ce0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of two noncovalently associated subunits, gp120 and gp41. Formation of gp120/gp41 oligomers is thought to be dependent on a 4-3 hydrophobic (heptad) repeat located in the amino-terminal region of the gp41 molecule. We have investigated the role of this heptad repeat in determining the oligomeric structure of gp41 by introducing its buried core residues into the first (a) and fourth (d) positions of the GCN4 leucine-zipper dimerization domain. The mutant peptides fold into trimeric, helical structures, as shown by circular dichroism and equilibrium sedimentation centrifugation. The 2.4 A resolution crystal structure of one such trimer reveals a parallel three-stranded, alpha-helical coiled coil. Thus, the buried core residues from the gp41 heptad repeat direct trimer formation. We suggest that the conserved amino-terminal heptad repeat within the gp41 ectodomain possesses trimerization specificity.
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===TRIMERIZATION SPECIFICITY IN HIV-1 GP41: ANALYSIS WITH A GCN4 LEUCINE ZIPPER MODEL===
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Trimerization specificity in HIV-1 gp41: analysis with a GCN4 leucine zipper model.,Shu W, Ji H, Lu M Biochemistry. 1999 Apr 27;38(17):5378-85. PMID:10220324<ref>PMID:10220324</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1ce0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10220324 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10220324}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1CE0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CE0 OCA].
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==Reference==
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Trimerization specificity in HIV-1 gp41: analysis with a GCN4 leucine zipper model., Shu W, Ji H, Lu M, Biochemistry. 1999 Apr 27;38(17):5378-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10220324 10220324]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ji, H.]]
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[[Category: Ji H]]
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[[Category: Lu, M.]]
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[[Category: Lu M]]
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[[Category: Shu, W.]]
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[[Category: Shu W]]
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[[Category: Coiled coil]]
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[[Category: Gp41]]
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[[Category: Hiv-1 envelope protein]]
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[[Category: Leucine zipper]]
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[[Category: Protein oligomerization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:36:46 2008''
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Current revision

TRIMERIZATION SPECIFICITY IN HIV-1 GP41: ANALYSIS WITH A GCN4 LEUCINE ZIPPER MODEL

PDB ID 1ce0

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