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1epf

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(New page: 200px<br /><applet load="1epf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1epf, resolution 1.85&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1epf.gif|left|200px]]<br /><applet load="1epf" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1epf, resolution 1.85&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)==
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The neural cell adhesion molecule NCAM, a member of the immunoglobulin, superfamily, mediates cell-cell recognition and adhesion via a homophilic, interaction. NCAM plays a key role during development and regeneration of, the nervous system and is involved in synaptic plasticity associated with, memory and learning. The 1.85 A crystal structure of the two N-terminal, extracellular domains of NCAM reported here provides a structural basis, for the homophilic interaction. The molecular packing of the two-domain, structure reveals a cross shaped antiparallel dimer, and provides, fundamental insight into trans-cellular recognition mediated by NCAM.
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<StructureSection load='1epf' size='340' side='right'caption='[[1epf]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1epf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EPF FirstGlance]. <br>
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1EPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epf OCA], [https://pdbe.org/1epf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1epf RCSB], [https://www.ebi.ac.uk/pdbsum/1epf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1epf ProSAT]</span></td></tr>
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Structural basis of cell-cell adhesion by NCAM., Kasper C, Rasmussen H, Kastrup JS, Ikemizu S, Jones EY, Berezin V, Bock E, Larsen IK, Nat Struct Biol. 2000 May;7(5):389-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10802736 10802736]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAM1_RAT NCAM1_RAT] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/1epf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1epf ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Berezin V]]
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[[Category: Berezin, V.]]
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[[Category: Bock E]]
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[[Category: Bock, E.]]
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[[Category: Ikemizu S]]
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[[Category: Ikemizu, S.]]
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[[Category: Jones EY]]
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[[Category: Jones, E.Y.]]
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[[Category: Kasper C]]
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[[Category: Kasper, C.]]
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[[Category: Kastrup JS]]
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[[Category: Kastrup, J.S.]]
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[[Category: Larsen IK]]
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[[Category: Larsen, I.K.]]
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[[Category: Rasmussen H]]
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[[Category: Rasmussen, H.]]
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[[Category: CA]]
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[[Category: glycoprotein]]
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[[Category: immunoglobulin fold]]
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[[Category: ncam]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:12:00 2007''
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Current revision

CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)

PDB ID 1epf

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