1ckm

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{{Seed}}
 
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[[Image:1ckm.png|left|200px]]
 
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==STRUCTURE OF TWO DIFFERENT CONFORMATIONS OF MRNA CAPPING ENZYME IN COMPLEX WITH GTP==
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The line below this paragraph, containing "STRUCTURE_1ckm", creates the "Structure Box" on the page.
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<StructureSection load='1ckm' size='340' side='right'caption='[[1ckm]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ckm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paramecium_bursaria_Chlorella_virus_1 Paramecium bursaria Chlorella virus 1]. The January 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Messenger RNA Capping'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_1 10.2210/rcsb_pdb/mom_2012_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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{{STRUCTURE_1ckm| PDB=1ckm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckm OCA], [https://pdbe.org/1ckm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckm RCSB], [https://www.ebi.ac.uk/pdbsum/1ckm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckm ProSAT]</span></td></tr>
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</table>
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===STRUCTURE OF TWO DIFFERENT CONFORMATIONS OF MRNA CAPPING ENZYME IN COMPLEX WITH GTP===
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== Function ==
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[https://www.uniprot.org/uniprot/MCE_PBCV1 MCE_PBCV1] mRNA capping. Transfers a GMP cap onto the end of mRNA that terminates with a 5'-diphosphate tail.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9160746 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/1ckm_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9160746}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1CKM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Paramecium_bursaria_chlorella_virus_1 Paramecium bursaria chlorella virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKM OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ckm ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes., Hakansson K, Doherty AJ, Shuman S, Wigley DB, Cell. 1997 May 16;89(4):545-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9160746 9160746]
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</StructureSection>
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[[Category: Paramecium bursaria chlorella virus 1]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Messenger RNA Capping]]
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[[Category: MRNA guanylyltransferase]]
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[[Category: Paramecium bursaria Chlorella virus 1]]
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[[Category: Doherty, A J.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Hakansson, K.]]
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[[Category: Doherty AJ]]
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[[Category: Wigley, D B.]]
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[[Category: Hakansson K]]
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[[Category: Capping enzyme]]
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[[Category: Wigley DB]]
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[[Category: Mrna]]
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[[Category: Nucleotidyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:52:35 2008''
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Current revision

STRUCTURE OF TWO DIFFERENT CONFORMATIONS OF MRNA CAPPING ENZYME IN COMPLEX WITH GTP

PDB ID 1ckm

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