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1cm7

From Proteopedia

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{{Seed}}
 
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[[Image:1cm7.png|left|200px]]
 
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==3-ISOPROPYLMALATE DEHYDROGENASE FROM ESCHERICHIA COLI==
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The line below this paragraph, containing "STRUCTURE_1cm7", creates the "Structure Box" on the page.
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<StructureSection load='1cm7' size='340' side='right'caption='[[1cm7]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cm7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CM7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cm7 OCA], [https://pdbe.org/1cm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cm7 RCSB], [https://www.ebi.ac.uk/pdbsum/1cm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cm7 ProSAT]</span></td></tr>
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{{STRUCTURE_1cm7| PDB=1cm7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEU3_ECOLI LEU3_ECOLI] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/1cm7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cm7 ConSurf].
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<div style="clear:both"></div>
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===3-ISOPROPYLMALATE DEHYDROGENASE FROM ESCHERICHIA COLI===
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==See Also==
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*[[Isopropylmalate dehydrogenase|Isopropylmalate dehydrogenase]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9086278}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9086278 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9086278}}
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==About this Structure==
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1CM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CM7 OCA].
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==Reference==
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Crystal structures of Escherichia coli and Salmonella typhimurium 3-isopropylmalate dehydrogenase and comparison with their thermophilic counterpart from Thermus thermophilus., Wallon G, Kryger G, Lovett ST, Oshima T, Ringe D, Petsko GA, J Mol Biol. 1997 Mar 14;266(5):1016-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9086278 9086278]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kryger, G.]]
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[[Category: Kryger G]]
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[[Category: Lovett, S T.]]
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[[Category: Lovett ST]]
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[[Category: Oshima, T.]]
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[[Category: Oshima T]]
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[[Category: Petsko, G A.]]
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[[Category: Petsko GA]]
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[[Category: Ringe, D.]]
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[[Category: Ringe D]]
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[[Category: Wallon, G.]]
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[[Category: Wallon G]]
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[[Category: Dehydrogenase]]
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[[Category: Leucine biosynthetic pathway]]
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[[Category: Nad-dependant enzyme]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:56:23 2008''
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Current revision

3-ISOPROPYLMALATE DEHYDROGENASE FROM ESCHERICHIA COLI

PDB ID 1cm7

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