1cof

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:44, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1cof.png|left|200px]]
 
-
<!--
+
==YEAST COFILIN, ORTHORHOMBIC CRYSTAL FORM==
-
The line below this paragraph, containing "STRUCTURE_1cof", creates the "Structure Box" on the page.
+
<StructureSection load='1cof' size='340' side='right'caption='[[1cof]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1cof]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COF FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cof OCA], [https://pdbe.org/1cof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cof RCSB], [https://www.ebi.ac.uk/pdbsum/1cof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cof ProSAT]</span></td></tr>
-
{{STRUCTURE_1cof| PDB=1cof | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===YEAST COFILIN, ORTHORHOMBIC CRYSTAL FORM===
+
[https://www.uniprot.org/uniprot/COFI_YEAST COFI_YEAST] Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton. In effect, yeast cofilin increases the rate of actin polymerization by making new ends available for actin subunit addition. Such a protein complex is important for the polarized growth of yeast cells.<ref>PMID:10231390</ref> <ref>PMID:11747431</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
<!--
+
Check<jmol>
-
The line below this paragraph, {{ABSTRACT_PUBMED_9145106}}, adds the Publication Abstract to the page
+
<jmolCheckbox>
-
(as it appears on PubMed at http://www.pubmed.gov), where 9145106 is the PubMed ID number.
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1cof_consurf.spt"</scriptWhenChecked>
-
-->
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
{{ABSTRACT_PUBMED_9145106}}
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cof ConSurf].
-
1COF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COF OCA].
+
<div style="clear:both"></div>
-
 
+
== References ==
-
==Reference==
+
<references/>
-
Structure determination of yeast cofilin., Fedorov AA, Lappalainen P, Fedorov EV, Drubin DG, Almo SC, Nat Struct Biol. 1997 May;4(5):366-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9145106 9145106]
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Single protein]]
+
[[Category: Almo SC]]
-
[[Category: Almo, S C.]]
+
[[Category: Drubin DG]]
-
[[Category: Drubin, D G.]]
+
[[Category: Fedorov AA]]
-
[[Category: Fedorov, A A.]]
+
[[Category: Fedorov EV]]
-
[[Category: Fedorov, E V.]]
+
[[Category: Lappalainen P]]
-
[[Category: Lappalainen, P.]]
+
-
[[Category: Actin-binding]]
+
-
[[Category: Cytoskeleton]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:01:15 2008''
+

Current revision

YEAST COFILIN, ORTHORHOMBIC CRYSTAL FORM

PDB ID 1cof

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cof"
Personal tools