1cow

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{{Seed}}
 
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[[Image:1cow.png|left|200px]]
 
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==BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH AUROVERTIN B==
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The line below this paragraph, containing "STRUCTURE_1cow", creates the "Structure Box" on the page.
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<StructureSection load='1cow' size='340' side='right'caption='[[1cow]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cow]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=AUR:AUROVERTIN+B'>AUR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1cow| PDB=1cow | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cow OCA], [https://pdbe.org/1cow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cow RCSB], [https://www.ebi.ac.uk/pdbsum/1cow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cow ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATPA_BOVIN ATPA_BOVIN] Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1cow_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cow ConSurf].
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<div style="clear:both"></div>
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===BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH AUROVERTIN B===
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==See Also==
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*[[ATPase 3D structures|ATPase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8692918}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8692918 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8692918}}
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==About this Structure==
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1COW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COW OCA].
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==Reference==
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The structure of bovine F1-ATPase complexed with the antibiotic inhibitor aurovertin B., van Raaij MJ, Abrahams JP, Leslie AG, Walker JE, Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):6913-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8692918 8692918]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Abrahams, J P.]]
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[[Category: Abrahams JP]]
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[[Category: Leslie, A G.W.]]
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[[Category: Leslie AGW]]
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[[Category: Raaij, M Van.]]
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[[Category: Walker JE]]
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[[Category: Walker, J E.]]
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[[Category: Van Raaij MJ]]
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[[Category: Atp phosphorylase]]
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[[Category: Atp synthase]]
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[[Category: F1-atpase]]
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[[Category: F1f atp synthase]]
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[[Category: Hydrogen ion transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:02:21 2008''
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Current revision

BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH AUROVERTIN B

PDB ID 1cow

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