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1cx6

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{{Seed}}
 
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[[Image:1cx6.png|left|200px]]
 
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==T4 LYSOZYME SUBSTITUTED WITH SELENOMETHIONINE==
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The line below this paragraph, containing "STRUCTURE_1cx6", creates the "Structure Box" on the page.
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<StructureSection load='1cx6' size='340' side='right'caption='[[1cx6]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CX6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1cx6| PDB=1cx6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cx6 OCA], [https://pdbe.org/1cx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cx6 RCSB], [https://www.ebi.ac.uk/pdbsum/1cx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cx6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/1cx6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cx6 ConSurf].
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<div style="clear:both"></div>
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===T4 LYSOZYME SUBSTITUTED WITH SELENOMETHIONINE===
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==See Also==
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10556025}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10556025 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia virus T4]]
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{{ABSTRACT_PUBMED_10556025}}
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[[Category: Large Structures]]
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[[Category: Baase WA]]
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==About this Structure==
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[[Category: Gassner NC]]
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1CX6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX6 OCA].
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[[Category: Matthews BW]]
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==Reference==
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Substitution with selenomethionine can enhance the stability of methionine-rich proteins., Gassner NC, Baase WA, Hausrath AC, Matthews BW, J Mol Biol. 1999 Nov 19;294(1):17-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10556025 10556025]
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[[Category: Enterobacteria phage t4]]
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[[Category: Lysozyme]]
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[[Category: Single protein]]
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[[Category: Baase, W A.]]
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[[Category: Gassner, N C.]]
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[[Category: Matthews, B W.]]
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[[Category: Protein engineering]]
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[[Category: Protein folding]]
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[[Category: Selenomethionine core mutant]]
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[[Category: T4 lysozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:41:37 2008''
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Current revision

T4 LYSOZYME SUBSTITUTED WITH SELENOMETHIONINE

PDB ID 1cx6

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