1exb

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(New page: 200px<br /><applet load="1exb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1exb, resolution 2.1&Aring;" /> '''STRUCTURE OF THE CYTO...)
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[[Image:1exb.gif|left|200px]]<br /><applet load="1exb" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1exb, resolution 2.1&Aring;" />
 
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'''STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS'''<br />
 
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==Overview==
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==STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS==
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The structure of the cytoplasmic assembly of voltage-dependent K+ channels, was solved by x-ray crystallography at 2.1 angstrom resolution. The, assembly includes the cytoplasmic (T1) domain of the integral membrane, alpha subunit together with the oxidoreductase beta subunit in a fourfold, symmetric T1(4)beta4 complex. An electrophysiological assay showed that, this complex is oriented with four T1 domains facing the transmembrane, pore and four beta subunits facing the cytoplasm. The transmembrane pore, communicates with the cytoplasm through lateral, negatively charged, openings above the T1(4)beta4 complex. The inactivation peptides of, voltage-dependent K(+) channels reach their site of action by entering, these openings.
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<StructureSection load='1exb' size='340' side='right'caption='[[1exb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1exb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EXB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1exb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exb OCA], [https://pdbe.org/1exb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1exb RCSB], [https://www.ebi.ac.uk/pdbsum/1exb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1exb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCAB2_RAT KCAB2_RAT] Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1exb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1exb ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1EXB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with NDP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EXB OCA].
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels., Gulbis JM, Zhou M, Mann S, MacKinnon R, Science. 2000 Jul 7;289(5476):123-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10884227 10884227]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Gulbis, J.M.]]
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[[Category: Gulbis JM]]
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[[Category: MacKinnon, R.]]
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[[Category: MacKinnon R]]
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[[Category: Mann, S.]]
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[[Category: Mann S]]
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[[Category: Zhou, M.]]
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[[Category: Zhou M]]
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[[Category: NDP]]
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[[Category: beta subunit]]
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[[Category: ion channel]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:23:50 2007''
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Current revision

STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS

PDB ID 1exb

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