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1d6s

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{{Seed}}
 
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[[Image:1d6s.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE K41A MUTANT OF O-ACETYLSERINE SULFHYDRYLASE COMPLEXED IN EXTERNAL ALDIMINE LINKAGE WITH METHIONINE==
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The line below this paragraph, containing "STRUCTURE_1d6s", creates the "Structure Box" on the page.
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<StructureSection load='1d6s' size='340' side='right'caption='[[1d6s]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d6s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D6S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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{{STRUCTURE_1d6s| PDB=1d6s | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d6s OCA], [https://pdbe.org/1d6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d6s RCSB], [https://www.ebi.ac.uk/pdbsum/1d6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d6s ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF THE K41A MUTANT OF O-ACETYLSERINE SULFHYDRYLASE COMPLEXED IN EXTERNAL ALDIMINE LINKAGE WITH METHIONINE===
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== Function ==
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[https://www.uniprot.org/uniprot/CYSK_SALTY CYSK_SALTY] Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_10452898}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 10452898 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/1d6s_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_10452898}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1D6S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6S OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d6s ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium., Burkhard P, Tai CH, Ristroph CM, Cook PF, Jansonius JN, J Mol Biol. 1999 Aug 27;291(4):941-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10452898 10452898]
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</StructureSection>
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[[Category: Cysteine synthase]]
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[[Category: Large Structures]]
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[[Category: Salmonella typhimurium]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Single protein]]
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[[Category: Burkhard P]]
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[[Category: Burkhard, P.]]
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[[Category: Cook PF]]
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[[Category: Cook, P F.]]
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[[Category: Jansonius JN]]
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[[Category: Jansonius, J N.]]
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[[Category: Ristroph CM]]
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[[Category: Ristroph, C M.]]
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[[Category: Tai CH]]
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[[Category: Tai, C H.]]
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[[Category: Beta replacement enzyme]]
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[[Category: Cysteine biosynthesis]]
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[[Category: K41a]]
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[[Category: Plp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:33:07 2008''
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Current revision

CRYSTAL STRUCTURE OF THE K41A MUTANT OF O-ACETYLSERINE SULFHYDRYLASE COMPLEXED IN EXTERNAL ALDIMINE LINKAGE WITH METHIONINE

PDB ID 1d6s

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