1dd6

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{{Seed}}
 
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[[Image:1dd6.png|left|200px]]
 
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==IMP-1 METALLO BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH A MERCAPTOCARBOXYLATE INHIBITOR==
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The line below this paragraph, containing "STRUCTURE_1dd6", creates the "Structure Box" on the page.
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<StructureSection load='1dd6' size='340' side='right'caption='[[1dd6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dd6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DD6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MCI:(2-MERCAPTOMETHYL-4-PHENYL-BUTYRYLIMINO)-(5-TETRAZOL-1-YLMETHYL-THIOPHEN-2-YL)-ACETIC+ACID'>MCI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1dd6| PDB=1dd6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dd6 OCA], [https://pdbe.org/1dd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dd6 RCSB], [https://www.ebi.ac.uk/pdbsum/1dd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dd6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dd/1dd6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dd6 ConSurf].
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<div style="clear:both"></div>
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===IMP-1 METALLO BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH A MERCAPTOCARBOXYLATE INHIBITOR===
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10757977}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10757977 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10757977}}
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==About this Structure==
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1DD6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DD6 OCA].
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==Reference==
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Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor., Concha NO, Janson CA, Rowling P, Pearson S, Cheever CA, Clarke BP, Lewis C, Galleni M, Frere JM, Payne DJ, Bateson JH, Abdel-Meguid SS, Biochemistry. 2000 Apr 18;39(15):4288-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10757977 10757977]
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[[Category: Beta-lactamase]]
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[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Single protein]]
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[[Category: Abdel-Meguid SS]]
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[[Category: Abdel-Meguid, S S.]]
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[[Category: Bateson JH]]
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[[Category: Bateson, J H.]]
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[[Category: Cheever CA]]
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[[Category: Cheever, C A.]]
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[[Category: Clarke BP]]
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[[Category: Clarke, B P.]]
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[[Category: Concha NO]]
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[[Category: Concha, N O.]]
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[[Category: Frere JM]]
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[[Category: Frere, J M.]]
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[[Category: Galleni M]]
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[[Category: Galleni, M.]]
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[[Category: Janson CA]]
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[[Category: Janson, C A.]]
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[[Category: Lewis C]]
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[[Category: Lewis, C.]]
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[[Category: Payne DJ]]
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[[Category: Payne, D J.]]
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[[Category: Pearson S]]
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[[Category: Pearson, S.]]
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[[Category: Rowling P]]
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[[Category: Rowling, P.]]
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[[Category: Imp-1 metallo beta-lactamase]]
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[[Category: Mercaptocarboxylate inhibitor]]
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[[Category: Metallo beta-lactamase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:50:54 2008''
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Current revision

IMP-1 METALLO BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH A MERCAPTOCARBOXYLATE INHIBITOR

PDB ID 1dd6

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