1dg5

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{{Seed}}
 
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[[Image:1dg5.png|left|200px]]
 
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==DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM==
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The line below this paragraph, containing "STRUCTURE_1dg5", creates the "Structure Box" on the page.
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<StructureSection load='1dg5' size='340' side='right'caption='[[1dg5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DG5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr>
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{{STRUCTURE_1dg5| PDB=1dg5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dg5 OCA], [https://pdbe.org/1dg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dg5 RCSB], [https://www.ebi.ac.uk/pdbsum/1dg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dg5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dg5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dg5 ConSurf].
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<div style="clear:both"></div>
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===DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM===
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10623528}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10623528 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10623528}}
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==About this Structure==
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1DG5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG5 OCA].
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==Reference==
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Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs., Li R, Sirawaraporn R, Chitnumsub P, Sirawaraporn W, Wooden J, Athappilly F, Turley S, Hol WG, J Mol Biol. 2000 Jan 14;295(2):307-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10623528 10623528]
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[[Category: Dihydrofolate reductase]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Athappilly F]]
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[[Category: Athappilly, F.]]
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[[Category: Chitnumsub P]]
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[[Category: Chitnumsub, P.]]
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[[Category: Hol WG]]
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[[Category: Hol, W G.]]
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[[Category: Li R]]
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[[Category: Li, R.]]
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[[Category: Sirawaraporn R]]
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[[Category: Sirawaraporn, R.]]
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[[Category: Sirawaraporn W]]
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[[Category: Sirawaraporn, W.]]
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[[Category: Turley S]]
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[[Category: Turley, S.]]
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[[Category: Wooden J]]
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[[Category: Wooden, J.]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Folateanalog]]
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[[Category: Nicotinamide adenine dinucleotide]]
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[[Category: Rossmann fold]]
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[[Category: Structure-based inhibitor design]]
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[[Category: Trimethoprim]]
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[[Category: Tuberculosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:01:52 2008''
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Current revision

DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM

PDB ID 1dg5

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