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1dmj

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BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 5,6-CYCLIC-TETRAHYDROPTERIDINE

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Retrieved from "http://52.214.119.220/wiki/index.php/1dmj"

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:1dmj.png|left|200px]]
-<!--
+==BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 5,6-CYCLIC-TETRAHYDROPTERIDINE==
-The line below this paragraph, containing "STRUCTURE_1dmj", creates the "Structure Box" on the page.
+<StructureSection load='1dmj' size='340' side='right'caption='[[1dmj]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1dmj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DMJ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AP4:7-AMINO-3,3A,4,5-TETRAHYDRO-8H-2-OXA-5,6,8,9B-TETRAAZA-CYCLOPENTA[A]NAPHTHALENE-1,9-DIONE'>AP4</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ITU:ETHYLISOTHIOUREA'>ITU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1dmj|  PDB=1dmj  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dmj OCA], [https://pdbe.org/1dmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dmj RCSB], [https://www.ebi.ac.uk/pdbsum/1dmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dmj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/1dmj_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dmj ConSurf].
+<div style="clear:both"></div>
-===BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 5,6-CYCLIC-TETRAHYDROPTERIDINE===
+==See Also==
+*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_11590164}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 11590164 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_11590164}}
-==About this Structure==
-DMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DMJ OCA].
-==Reference==
-Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin., Kotsonis P, Frohlich LG, Raman CS, Li H, Berg M, Gerwig R, Groehn V, Kang Y, Al-Masoudi N, Taghavi-Moghadam S, Mohr D, Munch U, Schnabel J, Martasek P, Masters BS, Strobel H, Poulos T, Matter H, Pfleiderer W, Schmidt HH, J Biol Chem. 2001 Dec 28;276(52):49133-41. Epub 2001 Oct 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11590164 11590164]
 [[Category: Bos taurus]]
-[[Category: Nitric-oxide synthase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Al-Masoudi N]]
-[[Category: Al-Masoudi, N.]]
+[[Category: Berg M]]
-[[Category: Berg, M.]]
+[[Category: Frohlich LG]]
-[[Category: Frohlich, L G.]]
+[[Category: Gerwig R]]
-[[Category: Gerwig, R.]]
+[[Category: Groehn V]]
-[[Category: Groehn, V.]]
+[[Category: Kang Y]]
-[[Category: Kang, Y.]]
+[[Category: Kotsonis P]]
-[[Category: Kotsonis, P.]]
+[[Category: Li H]]
-[[Category: Li, H.]]
+[[Category: Martasek P]]
-[[Category: Martasek, P.]]
+[[Category: Masters BS]]
-[[Category: Masters, B S.]]
+[[Category: Matter H]]
-[[Category: Matter, H.]]
+[[Category: Mohr D]]
-[[Category: Mohr, D.]]
+[[Category: Munch U]]
-[[Category: Munch, U.]]
+[[Category: Pfleiderer W]]
-[[Category: Pfleiderer, W.]]
+[[Category: Poulos T]]
-[[Category: Poulos, T.]]
+[[Category: Raman CS]]
-[[Category: Raman, C S.]]
+[[Category: Schmidt HH]]
-[[Category: Schmidt, H H.]]
+[[Category: Schnabel J]]
-[[Category: Schnabel, J.]]
+[[Category: Strobel H]]
-[[Category: Strobel, H.]]
+[[Category: Taghavi-Moghadam S]]
-[[Category: Taghavi-Moghadam, S.]]
-[[Category: Alpha-beta fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:17:54 2008''

1dmj

From Proteopedia

Current revision

BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 5,6-CYCLIC-TETRAHYDROPTERIDINE

Structural highlights

Function

Evolutionary Conservation

See Also

Contents

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