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1doh

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{{Seed}}
 
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[[Image:1doh.png|left|200px]]
 
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==STRUCTURE OF TRIHYDROXYNAPHTHALENE REDUCTASE IN COMPLEX WITH NADPH AND 4-NITRO-INDEN-1-ONE==
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The line below this paragraph, containing "STRUCTURE_1doh", creates the "Structure Box" on the page.
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<StructureSection load='1doh' size='340' side='right'caption='[[1doh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1doh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_grisea Pyricularia grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DOH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=NID:4-NITRO-INDEN-1-ONE'>NID</scene></td></tr>
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{{STRUCTURE_1doh| PDB=1doh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1doh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1doh OCA], [https://pdbe.org/1doh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1doh RCSB], [https://www.ebi.ac.uk/pdbsum/1doh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1doh ProSAT]</span></td></tr>
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</table>
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===STRUCTURE OF TRIHYDROXYNAPHTHALENE REDUCTASE IN COMPLEX WITH NADPH AND 4-NITRO-INDEN-1-ONE===
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== Function ==
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[https://www.uniprot.org/uniprot/T4HR_MAGO7 T4HR_MAGO7] Catalyzes the NADPH-dependent reduction of 1,3,6,8-tetrahydroxynaphthalene (T4HN) into (+)-scytalone and 1,3,8-trihydroxynaphthalene into (-)-vermelone. This enzyme is the biochemical target of several commercially important fungicides which are used to prevent blast disease in rice plants.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11342131}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11342131 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/1doh_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11342131}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1DOH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOH OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1doh ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis., Liao D, Basarab GS, Gatenby AA, Valent B, Jordan DB, Structure. 2001 Jan 10;9(1):19-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11342131 11342131]
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</StructureSection>
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[[Category: Magnaporthe grisea]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Pyricularia grisea]]
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[[Category: Tetrahydroxynaphthalene reductase]]
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[[Category: Basarab GS]]
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[[Category: Basarab, G S.]]
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[[Category: Gatenby AA]]
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[[Category: Gatenby, A A.]]
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[[Category: Jordan DB]]
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[[Category: Jordan, D B.]]
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[[Category: Liao DI]]
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[[Category: Liao, D I.]]
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[[Category: Dinucleotide binding fold]]
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[[Category: Protein-nadph-active site inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:22:47 2008''
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Current revision

STRUCTURE OF TRIHYDROXYNAPHTHALENE REDUCTASE IN COMPLEX WITH NADPH AND 4-NITRO-INDEN-1-ONE

PDB ID 1doh

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