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1don

From Proteopedia

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{{Seed}}
 
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[[Image:1don.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE MONOCYTE CHEMOATTRACTANT PROTEIN-1 DIMER USING HETERONUCLEAR, NMR, 20 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1don", creates the "Structure Box" on the page.
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<StructureSection load='1don' size='340' side='right'caption='[[1don]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1don]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DON FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1don FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1don OCA], [https://pdbe.org/1don PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1don RCSB], [https://www.ebi.ac.uk/pdbsum/1don PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1don ProSAT]</span></td></tr>
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{{STRUCTURE_1don| PDB=1don | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/1don_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1don ConSurf].
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<div style="clear:both"></div>
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===SOLUTION STRUCTURE OF THE MONOCYTE CHEMOATTRACTANT PROTEIN-1 DIMER USING HETERONUCLEAR, NMR, 20 STRUCTURES===
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==See Also==
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*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8639605}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8639605 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8639605}}
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==About this Structure==
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1DON is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DON OCA].
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==Reference==
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Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer., Handel TM, Domaille PJ, Biochemistry. 1996 May 28;35(21):6569-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8639605 8639605]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Domaille, P J.]]
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[[Category: Domaille PJ]]
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[[Category: Handel, T M.]]
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[[Category: Handel TM]]
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[[Category: Chemoattractant cytokine]]
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[[Category: High resolution structure]]
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[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:23:14 2008''
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Current revision

SOLUTION STRUCTURE OF THE MONOCYTE CHEMOATTRACTANT PROTEIN-1 DIMER USING HETERONUCLEAR, NMR, 20 STRUCTURES

PDB ID 1don

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