1dph

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{{Seed}}
 
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[[Image:1dph.png|left|200px]]
 
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==CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11==
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The line below this paragraph, containing "STRUCTURE_1dph", creates the "Structure Box" on the page.
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<StructureSection load='1dph' size='340' side='right'caption='[[1dph]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dph]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DPH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCE:1,2-DICHLOROETHANE'>DCE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_1dph| PDB=1dph | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dph OCA], [https://pdbe.org/1dph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dph RCSB], [https://www.ebi.ac.uk/pdbsum/1dph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dph ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INS_BOVIN INS_BOVIN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dp/1dph_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dph ConSurf].
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<div style="clear:both"></div>
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===CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11===
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==See Also==
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*[[Insulin 3D Structures|Insulin 3D Structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_1477273}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1477273 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1477273}}
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==About this Structure==
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1DPH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DPH OCA].
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==Reference==
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Conformational changes in cubic insulin crystals in the pH range 7-11., Gursky O, Badger J, Li Y, Caspar DL, Biophys J. 1992 Nov;63(5):1210-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1477273 1477273]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Badger, J.]]
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[[Category: Badger J]]
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[[Category: Caspar, D L.D.]]
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[[Category: Caspar DLD]]
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[[Category: Gursky, O.]]
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[[Category: Gursky O]]
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[[Category: Li, Y.]]
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[[Category: Li Y]]
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[[Category: Hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:25:09 2008''
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Current revision

CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11

PDB ID 1dph

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