1dqn

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{{Seed}}
 
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[[Image:1dqn.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH A TRANSITION STATE ANALOGUE==
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The line below this paragraph, containing "STRUCTURE_1dqn", creates the "Structure Box" on the page.
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<StructureSection load='1dqn' size='340' side='right'caption='[[1dqn]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dqn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DQN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMU:PHOSPHORIC+ACID+MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL]+ESTER'>IMU</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
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{{STRUCTURE_1dqn| PDB=1dqn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dqn OCA], [https://pdbe.org/1dqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dqn RCSB], [https://www.ebi.ac.uk/pdbsum/1dqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dqn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q24973_GIAIN Q24973_GIAIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dq/1dqn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dqn ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH A TRANSITION STATE ANALOGUE===
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 10841757 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10841757}}
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==About this Structure==
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1DQN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQN OCA].
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==Reference==
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Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,)., Shi W, Munagala NR, Wang CC, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC, Biochemistry. 2000 Jun 13;39(23):6781-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10841757 10841757]
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[[Category: Giardia intestinalis]]
[[Category: Giardia intestinalis]]
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[[Category: Hypoxanthine phosphoribosyltransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Almo SC]]
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[[Category: Almo, S C.]]
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[[Category: Furneaux RH]]
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[[Category: Furneaux, R H.]]
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[[Category: Grubmeyer C]]
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[[Category: Grubmeyer, C.]]
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[[Category: Li CM]]
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[[Category: Li, C M.]]
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[[Category: Munagala NR]]
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[[Category: Munagala, N R.]]
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[[Category: Schramm VL]]
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[[Category: Schramm, V L.]]
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[[Category: Shi W]]
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[[Category: Shi, W.]]
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[[Category: Tyler PC]]
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[[Category: Tyler, P C.]]
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[[Category: Wang CC]]
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[[Category: Wang, C C.]]
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[[Category: Mg ion]]
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[[Category: Protein-inhibitor complex]]
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[[Category: Pyrophosphate]]
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[[Category: Transition state analogue]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:28:24 2008''
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Current revision

CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH A TRANSITION STATE ANALOGUE

PDB ID 1dqn

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