1dt2

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{{Seed}}
 
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[[Image:1dt2.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B==
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The line below this paragraph, containing "STRUCTURE_1dt2", creates the "Structure Box" on the page.
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<StructureSection load='1dt2' size='340' side='right'caption='[[1dt2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dt2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DT2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dt2 OCA], [https://pdbe.org/1dt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dt2 RCSB], [https://www.ebi.ac.uk/pdbsum/1dt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dt2 ProSAT]</span></td></tr>
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{{STRUCTURE_1dt2| PDB=1dt2 | SCENE= }}
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</table>
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== Function ==
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===CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B===
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[https://www.uniprot.org/uniprot/ETB_STAAU ETB_STAAU] Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).<ref>PMID:2117445</ref> <ref>PMID:2384148</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 10752623 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dt2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_10752623}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dt2 ConSurf].
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1DT2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT2 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structural similarities and differences in Staphylococcus aureus exfoliative toxins A and B as revealed by their crystal structures., Papageorgiou AC, Plano LR, Collins CM, Acharya KR, Protein Sci. 2000 Mar;9(3):610-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10752623 10752623]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Acharya, K R.]]
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[[Category: Acharya KR]]
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[[Category: Collins, C M.]]
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[[Category: Collins CM]]
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[[Category: Papageorgiou, A C.]]
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[[Category: Papageorgiou AC]]
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[[Category: Plano, L R.W.]]
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[[Category: Plano LRW]]
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[[Category: Epidermolysis]]
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[[Category: Serine protease]]
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[[Category: Superantigen]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:34:35 2008''
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Current revision

CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B

PDB ID 1dt2

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