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1e3b

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{{Seed}}
 
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[[Image:1e3b.png|left|200px]]
 
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==CYCLOPHILIN 3 FROM C.ELEGANS COMPLEXED WITH AUP(ET)3==
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The line below this paragraph, containing "STRUCTURE_1e3b", creates the "Structure Box" on the page.
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<StructureSection load='1e3b' size='340' side='right'caption='[[1e3b]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1e3b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E3B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3EP:TRIETHYLPHOSPHANE'>3EP</scene>, <scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
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{{STRUCTURE_1e3b| PDB=1e3b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3b OCA], [https://pdbe.org/1e3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e3b RCSB], [https://www.ebi.ac.uk/pdbsum/1e3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYP3_CAEEL CYP3_CAEEL] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/1e3b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e3b ConSurf].
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<div style="clear:both"></div>
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===CYCLOPHILIN 3 FROM C.ELEGANS COMPLEXED WITH AUP(ET)3===
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==See Also==
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1E3B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3B OCA].
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==Reference==
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First Crystal Structure of a Medicinally Relevant Gold Protein Complex: Unexpected Binding of, Zou J, Taylor P, Dornan J, Robinson SP, Walkinshaw MD, Sadler PJ, Angew Chem Int Ed Engl. 2000 Aug 18;39(16):2931-2934. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11028014 11028014]
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[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dornan, J.]]
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[[Category: Dornan J]]
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[[Category: Robinson, S P.]]
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[[Category: Robinson SP]]
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[[Category: Sadler, P J.]]
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[[Category: Sadler PJ]]
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[[Category: Taylor, P.]]
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[[Category: Taylor P]]
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[[Category: Walkinshaw, M D.]]
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[[Category: Walkinshaw MD]]
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[[Category: Zou, J.]]
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[[Category: Zou J]]
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[[Category: Aupet3 adduct cyclophilin antiarthritic gold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:04:37 2008''
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Current revision

CYCLOPHILIN 3 FROM C.ELEGANS COMPLEXED WITH AUP(ET)3

PDB ID 1e3b

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