1ead

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{{Seed}}
 
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[[Image:1ead.png|left|200px]]
 
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==ATOMIC STRUCTURE OF THE CUBIC CORE OF THE PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1ead", creates the "Structure Box" on the page.
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<StructureSection load='1ead' size='340' side='right'caption='[[1ead]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ead]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EAD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAO:OXIDIZED+COENZYME+A'>CAO</scene></td></tr>
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{{STRUCTURE_1ead| PDB=1ead | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ead FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ead OCA], [https://pdbe.org/1ead PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ead RCSB], [https://www.ebi.ac.uk/pdbsum/1ead PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ead ProSAT]</span></td></tr>
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</table>
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===ATOMIC STRUCTURE OF THE CUBIC CORE OF THE PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX===
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== Function ==
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[https://www.uniprot.org/uniprot/ODP2_AZOVI ODP2_AZOVI] The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_8471601}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 8471601 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/1ead_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_8471601}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1EAD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EAD OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ead ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p)., Mattevi A, Obmolova G, Kalk KH, Teplyakov A, Hol WG, Biochemistry. 1993 Apr 20;32(15):3887-901. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8471601 8471601]
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</StructureSection>
[[Category: Azotobacter vinelandii]]
[[Category: Azotobacter vinelandii]]
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[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Hol WGJ]]
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[[Category: Hol, W G.J.]]
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[[Category: Mattevi A]]
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[[Category: Mattevi, A.]]
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[[Category: Dihydrolipoamide acetyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:24:12 2008''
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Current revision

ATOMIC STRUCTURE OF THE CUBIC CORE OF THE PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX

PDB ID 1ead

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