1ec9

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{{Seed}}
 
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[[Image:1ec9.png|left|200px]]
 
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==E. COLI GLUCARATE DEHYDRATASE BOUND TO XYLAROHYDROXAMATE==
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The line below this paragraph, containing "STRUCTURE_1ec9", creates the "Structure Box" on the page.
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<StructureSection load='1ec9' size='340' side='right'caption='[[1ec9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ec9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EC9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=XYH:XYLAROHYDROXAMATE'>XYH</scene></td></tr>
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{{STRUCTURE_1ec9| PDB=1ec9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ec9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ec9 OCA], [https://pdbe.org/1ec9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ec9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ec9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ec9 ProSAT]</span></td></tr>
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</table>
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===E. COLI GLUCARATE DEHYDRATASE BOUND TO XYLAROHYDROXAMATE===
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== Function ==
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[https://www.uniprot.org/uniprot/GUDD_ECOLI GUDD_ECOLI] Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_10769114}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 10769114 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/1ec9_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_10769114}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1EC9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EC9 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ec9 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli., Gulick AM, Hubbard BK, Gerlt JA, Rayment I, Biochemistry. 2000 Apr 25;39(16):4590-602. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10769114 10769114]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Glucarate dehydratase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Gerlt JA]]
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[[Category: Gerlt, J A.]]
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[[Category: Gulick AM]]
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[[Category: Gulick, A M.]]
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[[Category: Hubbard BK]]
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[[Category: Hubbard, B K.]]
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[[Category: Rayment I]]
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[[Category: Rayment, I.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:29:04 2008''
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Current revision

E. COLI GLUCARATE DEHYDRATASE BOUND TO XYLAROHYDROXAMATE

PDB ID 1ec9

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