1edn

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{{Seed}}
 
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[[Image:1edn.png|left|200px]]
 
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==HUMAN ENDOTHELIN-1==
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The line below this paragraph, containing "STRUCTURE_1edn", creates the "Structure Box" on the page.
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<StructureSection load='1edn' size='340' side='right'caption='[[1edn]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1edn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EDN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1edn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1edn OCA], [https://pdbe.org/1edn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1edn RCSB], [https://www.ebi.ac.uk/pdbsum/1edn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1edn ProSAT]</span></td></tr>
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{{STRUCTURE_1edn| PDB=1edn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EDN1_HUMAN EDN1_HUMAN] Endothelins are endothelium-derived vasoconstrictor peptides.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by X-ray crystallography to 2.18 A resolution. This intermediate-sized structure was solved by molecular replacement techniques using a fragment of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models derived from NMR data indicate some important differences, especially in the carboxy-terminal region of the molecule: the entire carboxy terminal tail (residues 16-21) is helical in the crystal structure, but not in any of the NMR structures. This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity.
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===HUMAN ENDOTHELIN-1===
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The crystal structure of human endothelin.,Janes RW, Peapus DH, Wallace BA Nat Struct Biol. 1994 May;1(5):311-9. PMID:7664037<ref>PMID:7664037</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1edn" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 7664037 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_7664037}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1EDN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EDN OCA].
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==Reference==
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The crystal structure of human endothelin., Janes RW, Peapus DH, Wallace BA, Nat Struct Biol. 1994 May;1(5):311-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7664037 7664037]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Janes, R W.]]
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[[Category: Janes RW]]
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[[Category: Wallace, B A.]]
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[[Category: Wallace BA]]
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[[Category: Signal polypeptide g-protein coupled-receptor ligand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:32:11 2008''
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Current revision

HUMAN ENDOTHELIN-1

PDB ID 1edn

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