1eep

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:01, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1eep.png|left|200px]]
 
-
<!--
+
==2.4 A RESOLUTION CRYSTAL STRUCTURE OF BORRELIA BURGDORFERI INOSINE 5'-MONPHOSPHATE DEHYDROGENASE IN COMPLEX WITH A SULFATE ION==
-
The line below this paragraph, containing "STRUCTURE_1eep", creates the "Structure Box" on the page.
+
<StructureSection load='1eep' size='340' side='right'caption='[[1eep]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1eep]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EEP FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1eep| PDB=1eep | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eep OCA], [https://pdbe.org/1eep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eep RCSB], [https://www.ebi.ac.uk/pdbsum/1eep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eep ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IMDH_BORBU IMDH_BORBU] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Essential for mouse infection by tick bite and critical for the survival in environments that appear to lack sufficient amounts of guanine, guanosine, and/or deoxyguanosine to support spirochete growth, such as mammalian host tissues.<ref>PMID:9268334</ref> <ref>PMID:19666713</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/1eep_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eep ConSurf].
 +
<div style="clear:both"></div>
-
===2.4 A RESOLUTION CRYSTAL STRUCTURE OF BORRELIA BURGDORFERI INOSINE 5'-MONPHOSPHATE DEHYDROGENASE IN COMPLEX WITH A SULFATE ION===
+
==See Also==
-
 
+
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10758003}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 10758003 is the PubMed ID number.
+
</StructureSection>
-
-->
+
[[Category: Borreliella burgdorferi]]
-
{{ABSTRACT_PUBMED_10758003}}
+
[[Category: Large Structures]]
-
 
+
[[Category: Cahoon M]]
-
==About this Structure==
+
[[Category: Hedstrom L]]
-
1EEP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EEP OCA].
+
[[Category: McMillan FM]]
-
 
+
[[Category: Petsko GA]]
-
==Reference==
+
[[Category: Ringe D]]
-
Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6., McMillan FM, Cahoon M, White A, Hedstrom L, Petsko GA, Ringe D, Biochemistry. 2000 Apr 18;39(15):4533-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10758003 10758003]
+
[[Category: White A]]
-
[[Category: Borrelia burgdorferi]]
+
-
[[Category: IMP dehydrogenase]]
+
-
[[Category: Single protein]]
+
-
[[Category: Cahoon, M.]]
+
-
[[Category: Hedstrom, L.]]
+
-
[[Category: McMillan, F M.]]
+
-
[[Category: Petsko, G A.]]
+
-
[[Category: Ringe, D.]]
+
-
[[Category: White, A.]]
+
-
[[Category: Alpha-beta barrel]]
+
-
[[Category: Imp dehydrogenase]]
+
-
[[Category: Impdh]]
+
-
[[Category: Loop-6]]
+
-
[[Category: Purine biosynthesis]]
+
-
[[Category: Tim barrel]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:34:52 2008''
+

Current revision

2.4 A RESOLUTION CRYSTAL STRUCTURE OF BORRELIA BURGDORFERI INOSINE 5'-MONPHOSPHATE DEHYDROGENASE IN COMPLEX WITH A SULFATE ION

PDB ID 1eep

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1eep"
Personal tools