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1egf

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{{Seed}}
 
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[[Image:1egf.png|left|200px]]
 
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==SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED BY NMR SPECTROSCOPY AND REFINED BY ENERGY MINIMIZATION WITH RESTRAINTS==
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The line below this paragraph, containing "STRUCTURE_1egf", creates the "Structure Box" on the page.
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<StructureSection load='1egf' size='340' side='right'caption='[[1egf]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1egf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The June 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Epidermal Growth Factor Receptor'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_6 10.2210/rcsb_pdb/mom_2010_6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EGF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1egf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1egf OCA], [https://pdbe.org/1egf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1egf RCSB], [https://www.ebi.ac.uk/pdbsum/1egf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1egf ProSAT]</span></td></tr>
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{{STRUCTURE_1egf| PDB=1egf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EGF_MOUSE EGF_MOUSE] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eg/1egf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1egf ConSurf].
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<div style="clear:both"></div>
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===SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED BY NMR SPECTROSCOPY AND REFINED BY ENERGY MINIMIZATION WITH RESTRAINTS===
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==See Also==
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*[[Epidermal growth factor|Epidermal growth factor]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_1731873}}, adds the Publication Abstract to the page
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[[Category: Epidermal Growth Factor Receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 1731873 is the PubMed ID number.
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_1731873}}
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==About this Structure==
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1EGF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EGF OCA].
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==Reference==
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Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints., Montelione GT, Wuthrich K, Burgess AW, Nice EC, Wagner G, Gibson KD, Scheraga HA, Biochemistry. 1992 Jan 14;31(1):236-49. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1731873 1731873]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Montelione, G T.]]
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[[Category: Montelione GT]]
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[[Category: Scheraga, H A.]]
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[[Category: Scheraga HA]]
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[[Category: Wuthrich, K.]]
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[[Category: Wuthrich K]]
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[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:39:34 2008''
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Current revision

SOLUTION STRUCTURE OF MURINE EPIDERMAL GROWTH FACTOR DETERMINED BY NMR SPECTROSCOPY AND REFINED BY ENERGY MINIMIZATION WITH RESTRAINTS

PDB ID 1egf

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