1eku

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[[Image:1eku.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA==
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The line below this paragraph, containing "STRUCTURE_1eku", creates the "Structure Box" on the page.
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<StructureSection load='1eku' size='340' side='right'caption='[[1eku]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1eku]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EKU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1eku| PDB=1eku | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eku OCA], [https://pdbe.org/1eku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eku RCSB], [https://www.ebi.ac.uk/pdbsum/1eku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eku ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IFNG_HUMAN IFNG_HUMAN] In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:[https://omim.org/entry/609135 609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
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== Function ==
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[https://www.uniprot.org/uniprot/IFNG_HUMAN IFNG_HUMAN] Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
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===CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA===
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==See Also==
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*[[Interferon 3D structures|Interferon 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 10860730 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10860730}}
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==About this Structure==
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1EKU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EKU OCA].
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==Reference==
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Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma., Landar A, Curry B, Parker MH, DiGiacomo R, Indelicato SR, Nagabhushan TL, Rizzi G, Walter MR, J Mol Biol. 2000 May 26;299(1):169-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10860730 10860730]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Curry, B.]]
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[[Category: Curry B]]
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[[Category: DiGiacomo, R.]]
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[[Category: DiGiacomo R]]
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[[Category: Indelicato, S R.]]
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[[Category: Indelicato SR]]
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[[Category: Landar, A.]]
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[[Category: Landar A]]
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[[Category: Parker, M H.]]
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[[Category: Parker MH]]
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[[Category: Walter, M R.]]
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[[Category: Walter MR]]
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[[Category: Cytokine]]
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[[Category: Interferon]]
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[[Category: Protein engineering]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:54:33 2008''
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Current revision

CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA

PDB ID 1eku

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