1ems

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{{Seed}}
 
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[[Image:1ems.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE C. ELEGANS NITFHIT PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1ems", creates the "Structure Box" on the page.
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<StructureSection load='1ems' size='340' side='right'caption='[[1ems]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ems]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_1ems| PDB=1ems | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ems FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ems OCA], [https://pdbe.org/1ems PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ems RCSB], [https://www.ebi.ac.uk/pdbsum/1ems PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ems ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF THE C. ELEGANS NITFHIT PROTEIN===
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== Function ==
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[https://www.uniprot.org/uniprot/NFT1_CAEEL NFT1_CAEEL] Cleaves A-5'-PPP-5'A to yield AMP and ADP.<ref>PMID:10959838</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_10959838}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 10959838 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/1ems_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_10959838}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1EMS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ems ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers., Pace HC, Hodawadekar SC, Draganescu A, Huang J, Bieganowski P, Pekarsky Y, Croce CM, Brenner C, Curr Biol. 2000 Jul 27-Aug 10;10(15):907-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10959838 10959838]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bieganowski, P.]]
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[[Category: Bieganowski P]]
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[[Category: Brenner, C.]]
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[[Category: Brenner C]]
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[[Category: Croce, C M.]]
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[[Category: Croce CM]]
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[[Category: Draganescu, A.]]
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[[Category: Draganescu A]]
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[[Category: Hodawadekar, S C.]]
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[[Category: Hodawadekar SC]]
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[[Category: Huang, J.]]
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[[Category: Huang J]]
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[[Category: Pace, H C.]]
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[[Category: Pace HC]]
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[[Category: Pekarsky, Y.]]
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[[Category: Pekarsky Y]]
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[[Category: Cancer]]
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[[Category: Diadenosine polyphosphate hydrolase]]
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[[Category: Fhit]]
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[[Category: Histidine triad]]
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[[Category: Nitrilase]]
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[[Category: Nucleotide-binding protein]]
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[[Category: Rosetta stone]]
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[[Category: Tumor suppressor]]
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[[Category: Worm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:59:56 2008''
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Current revision

CRYSTAL STRUCTURE OF THE C. ELEGANS NITFHIT PROTEIN

PDB ID 1ems

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