1eoh

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{{Seed}}
 
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[[Image:1eoh.png|left|200px]]
 
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==GLUTATHIONE TRANSFERASE P1-1==
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The line below this paragraph, containing "STRUCTURE_1eoh", creates the "Structure Box" on the page.
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<StructureSection load='1eoh' size='340' side='right'caption='[[1eoh]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1eoh]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EOH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eoh OCA], [https://pdbe.org/1eoh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eoh RCSB], [https://www.ebi.ac.uk/pdbsum/1eoh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eoh ProSAT]</span></td></tr>
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{{STRUCTURE_1eoh| PDB=1eoh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/1eoh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eoh ConSurf].
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<div style="clear:both"></div>
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===GLUTATHIONE TRANSFERASE P1-1===
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10970734}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10970734 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10970734}}
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==About this Structure==
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1EOH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EOH OCA].
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==Reference==
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Structures of thermolabile mutants of human glutathione transferase P1-1., Rossjohn J, McKinstry WJ, Oakley AJ, Parker MW, Stenberg G, Mannervik B, Dragani B, Cocco R, Aceto A, J Mol Biol. 2000 Sep 15;302(2):295-302. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10970734 10970734]
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[[Category: Glutathione transferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aceto, A.]]
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[[Category: Aceto A]]
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[[Category: Cocco, R.]]
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[[Category: Cocco R]]
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[[Category: Dragani, B.]]
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[[Category: Dragani B]]
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[[Category: Mannervik, B.]]
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[[Category: Mannervik B]]
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[[Category: McKinstry, W J.]]
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[[Category: McKinstry WJ]]
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[[Category: Oakley, A J.]]
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[[Category: Oakley AJ]]
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[[Category: Parker, M W.]]
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[[Category: Parker MW]]
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[[Category: Rossjohn, J.]]
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[[Category: Rossjohn J]]
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[[Category: Stenberg, G.]]
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[[Category: Stenberg G]]
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[[Category: Glutathione transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:18:38 2008''
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Current revision

GLUTATHIONE TRANSFERASE P1-1

PDB ID 1eoh

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OCA

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