1ep2

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{{Seed}}
 
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[[Image:1ep2.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B COMPLEXED WITH OROTATE==
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The line below this paragraph, containing "STRUCTURE_1ep2", creates the "Structure Box" on the page.
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<StructureSection load='1ep2' size='340' side='right'caption='[[1ep2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ep2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EP2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
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{{STRUCTURE_1ep2| PDB=1ep2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ep2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ep2 OCA], [https://pdbe.org/1ep2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ep2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ep2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ep2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYRDB_LACLM PYRDB_LACLM] Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor. Can not use fumarate as an electron acceptor.<ref>PMID:8021180</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/1ep2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ep2 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B COMPLEXED WITH OROTATE===
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==See Also==
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11188687 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11188687}}
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==About this Structure==
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1EP2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EP2 OCA].
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==Reference==
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Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster., Rowland P, Norager S, Jensen KF, Larsen S, Structure. 2000 Dec 15;8(12):1227-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11188687 11188687]
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[[Category: Dihydroorotate oxidase]]
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[[Category: Lactococcus lactis]]
[[Category: Lactococcus lactis]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Jensen, K F.]]
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[[Category: Jensen KF]]
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[[Category: Larsen, S.]]
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[[Category: Larsen S]]
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[[Category: Norager, S.]]
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[[Category: Norager S]]
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[[Category: Rowland, P.]]
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[[Category: Rowland P]]
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[[Category: Heterotetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:25:02 2008''
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Current revision

CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B COMPLEXED WITH OROTATE

PDB ID 1ep2

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