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1epp

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ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-130,693 (MAS PHE LYS+MTF STA MBA)

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1epp"

Categories: Cryphonectria parasitica | Large Structures | Blundell TL | Cooper JB | Wallace BA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:1epp.png|left|200px]]
-<!--
+==ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-130,693 (MAS PHE LYS+MTF STA MBA)==
-The line below this paragraph, containing "STRUCTURE_1epp", creates the "Structure Box" on the page.
+<StructureSection load='1epp' size='340' side='right'caption='[[1epp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1epp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EPP FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1Z1:N-(DIMETHYLSULFAMOYL)-L-PHENYLALANYL-N-[(1S,2S)-2-HYDROXY-4-{[(2S)-2-METHYLBUTYL]AMINO}-1-(2-METHYLPROPYL)-4-OXOBUTYL]-N~6~-(METHYLCARBAMOTHIOYL)-L-LYSINAMIDE'>1Z1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1epp|  PDB=1epp  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1epp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epp OCA], [https://pdbe.org/1epp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1epp RCSB], [https://www.ebi.ac.uk/pdbsum/1epp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1epp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CARP_CRYPA CARP_CRYPA]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/1epp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1epp ConSurf].
+<div style="clear:both"></div>
-===ANALYSES OF LIGAND BINDING IN FIVE ENDOTHIAPEPSIN CRYSTAL COMPLEXES AND THEIR USE IN THE DESIGN AND EVALUATION OF NOVEL RENIN INHIBITORS===
+==See Also==
+*[[Pepsin|Pepsin]]
+*[[Proteinase 3D structures|Proteinase 3D structures]]
-<!--
+__TOC__
-The line below this paragraph, {{ABSTRACT_PUBMED_8254610}}, adds the Publication Abstract to the page
+</StructureSection>
-(as it appears on PubMed at http://www.pubmed.gov), where 8254610 is the PubMed ID number.
+[[Category: Cryphonectria parasitica]]
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_8254610}}
+[[Category: Blundell TL]]
+[[Category: Cooper JB]]
-==About this Structure==
+[[Category: Wallace BA]]
-EPP is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPP OCA].
-==Reference==
-Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors., Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT, et al., J Med Chem. 1993 Nov 26;36(24):3809-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8254610 8254610]
-[[Category: Endothiapepsin]]
-[[Category: Single protein]]
-[[Category: Blundell, T L.]]
-[[Category: Cooper, J B.]]
-[[Category: Wallace, B A.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 01:32:55 2008''

1epp

From Proteopedia

Current revision

ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-130,693 (MAS PHE LYS+MTF STA MBA)

Structural highlights

Function

Evolutionary Conservation

See Also

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