1ev8

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{{Seed}}
 
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[[Image:1ev8.png|left|200px]]
 
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==CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI==
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The line below this paragraph, containing "STRUCTURE_1ev8", creates the "Structure Box" on the page.
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<StructureSection load='1ev8' size='340' side='right'caption='[[1ev8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ev8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EV8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene></td></tr>
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{{STRUCTURE_1ev8| PDB=1ev8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ev8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ev8 OCA], [https://pdbe.org/1ev8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ev8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ev8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ev8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/1ev8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ev8 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI===
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10841779}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10841779 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10841779}}
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==About this Structure==
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1EV8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EV8 OCA].
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==Reference==
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Catalytic cysteine of thymidylate synthase is activated upon substrate binding., Phan J, Mahdavian E, Nivens MC, Minor W, Berger S, Spencer HT, Dunlap RB, Lebioda L, Biochemistry. 2000 Jun 13;39(23):6969-78. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10841779 10841779]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Thymidylate synthase]]
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[[Category: Berger S]]
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[[Category: Berger, S.]]
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[[Category: Dunlap RB]]
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[[Category: Dunlap, R B.]]
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[[Category: Lebioda L]]
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[[Category: Lebioda, L.]]
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[[Category: Mahdavian E]]
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[[Category: Mahdavian, E.]]
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[[Category: Minor W]]
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[[Category: Minor, W.]]
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[[Category: Nivens MC]]
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[[Category: Nivens, M C.]]
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[[Category: Phan J]]
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[[Category: Phan, J.]]
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[[Category: Spencer HT]]
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[[Category: Spencer, H T.]]
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[[Category: Cys167 e. coli thymidylate synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:04:26 2008''
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Current revision

CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI

PDB ID 1ev8

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