1ew1

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{{Seed}}
 
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[[Image:1ew1.png|left|200px]]
 
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==RECA PROTEIN-BOUND SINGLE-STRANDED DNA==
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The line below this paragraph, containing "STRUCTURE_1ew1", creates the "Structure Box" on the page.
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<StructureSection load='1ew1' size='340' side='right'caption='[[1ew1]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ew1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EW1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ew1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ew1 OCA], [https://pdbe.org/1ew1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ew1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ew1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ew1 ProSAT]</span></td></tr>
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{{STRUCTURE_1ew1| PDB=1ew1 | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The family of proteins that are homologous to RecA protein of Escherichia coli is essential to homologous genetic recombination in various organisms including viruses, bacteria, lower eukaryotes, and mammals. In the presence of ATP (or ATPgammaS), these proteins form helical filaments containing single-stranded DNA at the center. The single-stranded DNA bound to RecA protein is extended 1.5 times relative to B-form DNA with the same sequence, and the extension is critical to pairing with homologous double-stranded DNA. This pairing reaction, called homologous pairing, is a key reaction in homologous recombination. In this NMR study, we determined a three-dimensional structure of the single-stranded DNA bound to RecA protein. The DNA structure contains novel deoxyribose-base stacking in which the 2'-methylene moiety of each deoxyribose is placed above the base of the following residue, instead of normal stacking of adjacent bases. As a result of this deoxyribose-base stacking, bases of the single-stranded DNA are spaced out nearly 5 A. Thus, this novel structure well explains the axial extension of DNA in the RecA-filaments relative to B-form DNA and leads to a possible interpretation of the role of this extension in homologous pairing.
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===RECA PROTEIN-BOUND SINGLE-STRANDED DNA===
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An extended DNA structure through deoxyribose-base stacking induced by RecA protein.,Nishinaka T, Ito Y, Yokoyama S, Shibata T Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6623-8. PMID:9192615<ref>PMID:9192615</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9192615}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ew1" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9192615 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9192615}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EW1 OCA].
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[[Category: Ito Y]]
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[[Category: Nishinaka T]]
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==Reference==
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[[Category: Shibata T]]
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An extended DNA structure through deoxyribose-base stacking induced by RecA protein., Nishinaka T, Ito Y, Yokoyama S, Shibata T, Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6623-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9192615 9192615]
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[[Category: Yokoyama S]]
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[[Category: Ito, Y.]]
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[[Category: Nishinaka, T.]]
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[[Category: Shibata, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: Deoxyribose-base stacking]]
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[[Category: Single-stranded dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:06:32 2008''
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Current revision

RECA PROTEIN-BOUND SINGLE-STRANDED DNA

PDB ID 1ew1

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