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1exf

From Proteopedia

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{{Seed}}
 
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[[Image:1exf.png|left|200px]]
 
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<!--
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==EXFOLIATIVE TOXIN A==
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The line below this paragraph, containing "STRUCTURE_1exf", creates the "Structure Box" on the page.
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<StructureSection load='1exf' size='340' side='right'caption='[[1exf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1exf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EXF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
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{{STRUCTURE_1exf| PDB=1exf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1exf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1exf OCA], [https://pdbe.org/1exf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1exf RCSB], [https://www.ebi.ac.uk/pdbsum/1exf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1exf ProSAT]</span></td></tr>
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</table>
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===EXFOLIATIVE TOXIN A===
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== Function ==
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[https://www.uniprot.org/uniprot/ETA_STAAU ETA_STAAU] Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).<ref>PMID:2117445</ref> <ref>PMID:2384148</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_9048539}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9048539 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/1exf_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9048539}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1EXF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [http://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EXF OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1exf ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease., Vath GM, Earhart CA, Rago JV, Kim MH, Bohach GA, Schlievert PM, Ohlendorf DH, Biochemistry. 1997 Feb 18;36(7):1559-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9048539 9048539]
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<references/>
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[[Category: Single protein]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Unidentified]]
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[[Category: Bohach GA]]
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[[Category: Bohach, G A.]]
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[[Category: Earhart CA]]
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[[Category: Earhart, C A.]]
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[[Category: Kim MH]]
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[[Category: Kim, M H.]]
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[[Category: Ohlendorf DH]]
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[[Category: Ohlendorf, D H.]]
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[[Category: Rago JV]]
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[[Category: Rago, J V.]]
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[[Category: Schlievert PM]]
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[[Category: Schlievert, P M.]]
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[[Category: Vath GM]]
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[[Category: Vath, G M.]]
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[[Category: Hydrolase]]
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[[Category: Serine protease]]
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[[Category: Superantigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:10:05 2008''
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Current revision

EXFOLIATIVE TOXIN A

PDB ID 1exf

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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