This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ezf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:09, 7 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1ezf.png|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE==
-
The line below this paragraph, containing "STRUCTURE_1ezf", creates the "Structure Box" on the page.
+
<StructureSection load='1ezf' size='340' side='right'caption='[[1ezf]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ezf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EZF FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IN0:N-{2-[TRANS-7-CHLORO-1-(2,2-DIMETHYL-PROPYL)+-5-NAPHTHALEN-1-YL-2-OXO-1,2,3,5-TETRAHYDRO-BENZO[E]+[1,4]OXAZEPIN-3-YL]-ACETYL}-ASPARTIC+ACID'>IN0</scene></td></tr>
-
{{STRUCTURE_1ezf| PDB=1ezf | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ezf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ezf OCA], [https://pdbe.org/1ezf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ezf RCSB], [https://www.ebi.ac.uk/pdbsum/1ezf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ezf ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ez/1ezf_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ezf ConSurf].
 +
<div style="clear:both"></div>
-
===CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE===
+
==See Also==
-
 
+
*[[Squalene synthase|Squalene synthase]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10896663}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 10896663 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_10896663}}
+
-
 
+
-
==About this Structure==
+
-
1EZF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZF OCA].
+
-
 
+
-
==Reference==
+
-
Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis., Pandit J, Danley DE, Schulte GK, Mazzalupo S, Pauly TA, Hayward CM, Hamanaka ES, Thompson JF, Harwood HJ Jr, J Biol Chem. 2000 Sep 29;275(39):30610-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10896663 10896663]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Squalene synthase]]
+
[[Category: Danley DE]]
-
[[Category: Danley, D E.]]
+
[[Category: Hamanaka ES]]
-
[[Category: Hamanaka, E S.]]
+
[[Category: Harwood HJ]]
-
[[Category: Harwood, H J.]]
+
[[Category: Hayward CM]]
-
[[Category: Hayward, C M.]]
+
[[Category: Mazzalupo SM]]
-
[[Category: Mazzalupo, S M.]]
+
[[Category: Pandit J]]
-
[[Category: Pandit, J.]]
+
[[Category: Pauly TA]]
-
[[Category: Pauly, T A.]]
+
[[Category: Schulte GK]]
-
[[Category: Schulte, G K.]]
+
[[Category: Thompson JF]]
-
[[Category: Thompson, J F.]]
+
-
[[Category: All alpha-helix]]
+
-
[[Category: Isoprenoid synthase fold]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:15:07 2008''
+

Current revision

CRYSTAL STRUCTURE OF HUMAN SQUALENE SYNTHASE

PDB ID 1ezf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ezf"
Personal tools