1f0c

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{{Seed}}
 
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[[Image:1f0c.png|left|200px]]
 
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==STRUCTURE OF THE VIRAL SERPIN CRMA==
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The line below this paragraph, containing "STRUCTURE_1f0c", creates the "Structure Box" on the page.
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<StructureSection load='1f0c' size='340' side='right'caption='[[1f0c]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f0c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F0C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
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{{STRUCTURE_1f0c| PDB=1f0c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0c OCA], [https://pdbe.org/1f0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f0c RCSB], [https://www.ebi.ac.uk/pdbsum/1f0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPI2_CWPXB SPI2_CWPXB] Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a "cross-class" interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B.<ref>PMID:1339309</ref> <ref>PMID:8034697</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/1f0c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f0c ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF THE VIRAL SERPIN CRMA===
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==See Also==
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*[[Serpin 3D structures|Serpin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10903953}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10903953 is the PubMed ID number.
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</StructureSection>
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[[Category: Cowpox virus]]
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{{ABSTRACT_PUBMED_10903953}}
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[[Category: Large Structures]]
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[[Category: Bankston LA]]
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==About this Structure==
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[[Category: Liddington RC]]
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1F0C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Cow_pox_virus Cow pox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0C OCA].
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[[Category: Renatus M]]
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[[Category: Salvesen GS]]
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==Reference==
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[[Category: Snipas SJ]]
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Crystal structure of the apoptotic suppressor CrmA in its cleaved form., Renatus M, Zhou Q, Stennicke HR, Snipas SJ, Turk D, Bankston LA, Liddington RC, Salvesen GS, Structure. 2000 Jul 15;8(7):789-97. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10903953 10903953]
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[[Category: Stennicke HR]]
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[[Category: Cow pox virus]]
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[[Category: Turk D]]
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[[Category: Protein complex]]
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[[Category: Zhou Q]]
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[[Category: Bankston, L A.]]
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[[Category: Liddington, R C.]]
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[[Category: Renatus, M.]]
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[[Category: Salvesen, G S.]]
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[[Category: Snipas, S J.]]
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[[Category: Stennicke, H R.]]
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[[Category: Turk, D.]]
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[[Category: Zhou, Q.]]
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[[Category: Apoptosis]]
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[[Category: Caspase inhibitor]]
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[[Category: Protease inhibitor]]
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[[Category: Serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:17:37 2008''
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Current revision

STRUCTURE OF THE VIRAL SERPIN CRMA

PDB ID 1f0c

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