1f23

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:09, 7 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1f23.png|left|200px]]
 
-
<!--
+
==CONTRIBUTION OF A BURIED HYDROGEN BOND TO HIV-1 ENVELOPE GLYCOPROTEIN STRUCTURE AND FUNCTION==
-
The line below this paragraph, containing "STRUCTURE_1f23", creates the "Structure Box" on the page.
+
<StructureSection load='1f23' size='340' side='right'caption='[[1f23]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1f23]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F23 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f23 OCA], [https://pdbe.org/1f23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f23 RCSB], [https://www.ebi.ac.uk/pdbsum/1f23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f23 ProSAT]</span></td></tr>
-
{{STRUCTURE_1f23| PDB=1f23 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q89797_9HIV1 Q89797_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[SAAS:SAAS000328_004_020447][RuleBase:RU004292] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/1f23_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f23 ConSurf].
 +
<div style="clear:both"></div>
-
===CONTRIBUTION OF A BURIED HYDROGEN BOND TO HIV-1 ENVELOPE GLYCOPROTEIN STRUCTURE AND FUNCTION===
+
==See Also==
-
 
+
*[[Gp41 3D Structures|Gp41 3D Structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_11258890}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 11258890 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_11258890}}
+
-
 
+
-
==About this Structure==
+
-
1F23 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F23 OCA].
+
-
 
+
-
==Reference==
+
-
Structural and functional analysis of the HIV gp41 core containing an Ile573 to Thr substitution: implications for membrane fusion., Liu J, Shu W, Fagan MB, Nunberg JH, Lu M, Biochemistry. 2001 Mar 6;40(9):2797-807. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11258890 11258890]
+
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Fagan, M.]]
+
[[Category: Fagan M]]
-
[[Category: Liu, J.]]
+
[[Category: Liu J]]
-
[[Category: Lu, M.]]
+
[[Category: Lu M]]
-
[[Category: Nunberg, J H.]]
+
[[Category: Nunberg JH]]
-
[[Category: Shu, W.]]
+
[[Category: Shu W]]
-
[[Category: Gp41]]
+
-
[[Category: Hiv-1 entry]]
+
-
[[Category: Hiv-1 envelope protein]]
+
-
[[Category: Membrane fusion]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:21:35 2008''
+

Current revision

CONTRIBUTION OF A BURIED HYDROGEN BOND TO HIV-1 ENVELOPE GLYCOPROTEIN STRUCTURE AND FUNCTION

PDB ID 1f23

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f23"
Personal tools